Human Leukotriene B4 R1 MAb (Clone 203/14F11) (25 UG)【科瑞奥博】

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Human Leukotriene B4 R1 MAb (Clone 203/14F11) (25 UG)

货号： MAB099-SP 基本售价： 1467.3 元规格： -

产品信息

概述
货号	MAB099-SP
别名	BLT1; chemokine receptor-like 1; CMKRL1; leukotriene B4 receptor; LTB4R; LTB4R1; LTBR1; P2Y purinoceptor 7; purinergic receptor P2Y, G-protein coupled, 7
全称	Leukotriene B4 Receptor 1
反应种属	Human
应用	Flow Cytometry(0.25 µg/10⁶cells)
目标/特异性	Recognizes human Leukotriene B4 R1 (Pettersson, A. et al. (2000) Biochem. Biophys. Res. Commun. 279:520).
使用方法	Flow Cytometry: 0.25 µg/10⁶cells
来源	Reconstitute at 0.5 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	1241 (Human)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Low leukotriene B4 receptor 1 leads to ALOX5 downregulation at diagnosis of chronic myeloid leukemia. Authors: Lucas C, Harris R, Giannoudis A, McDonald E, Clark R Haematologica, 2014;99(11):1710-5. Species: Human Sample Type: Whole Cells Application: Flow Analysis of HLDA9 mAbs on plasmacytoid dendritic cells. Authors: Cabezon R, Sintes J, Llinas L, Benitez-Ribas D Immunol. Lett., 2011;134(2):167-73. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	HeLa cervical epithelial carcinoma cell line transfected with human Leukotriene B4 R1
内毒素水平	<0.10 EU per 1 μg of the antibody by the LAL method.
生物活性	Human
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	Polymorphonuclear granulocytes secrete the lipid chemotactic mediator Leukotriene B4 (LTB4) in response to inflammatory stimuli (1). Neutrophils, monocytes and lymphocytes respond to LTB4 via specific receptors localized on the cell surface (2-4). The high affinity LTB4 Receptor known as BLT1 is only expressed on leukocytes (5-7) while a second low affinity receptor BLT2 is expressed more ubiquitously (8, 9). The BLT1 and BLT2 are G-protein linked seven-transmembrane spanning receptors that share about 37-45% amino acid identity (8, 9).
运输条件	Blue Ice
存放说明	4℃
参考文献	Samuelsson, B. et al. (1987) Science 237:1171. Brom, J. and W. Konig (1989) Immunology 68:479. Patry, C. et al. (1996) Prostaglandins, Leukotrienes and Essential Fatty Acids 54:361. Dasari, V.R. et al. (2000) Immunopharm. 48:157. Pettersson, A. et al. (2000) Biochem. Biophys. Res. Comm. 279:520. Yokomizo, T. et al. (1997) Nature 387:620. Kato, K. et al. (2000) J. Exp. Med. 192:413. Yokomizo, T. et al. (2000) J. Exp. Med. 192:421. Kamohara, M. et al. (2000) J. Biol. Chem. 275:27000.

参考图片

Detection of Leukotriene B4 R1 in Human Blood Monocytes by Flow Cytometry. Human peripheral blood monoctyes were stained with Mouse Anti-Human CD14 APC‑conjugated Monoclonal Antibody (Catalog # FAB3832A) and either (A) Mouse Anti-Human Leukotriene B4 R1 Monoclonal Antibody (Catalog # MAB099) or
(B) Mouse IgG₁ Isotype Control (Catalog # MAB002) followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B). View our protocol for Staining Membrane-associated Proteins.