Human Galectin-3 MAb (Clone 194804) (25 UG)【科瑞奥博】

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Human Galectin-3 MAb (Clone 194804) (25 UG)

货号： MAB1154-SP 基本售价： 1467.3 元规格： -

产品信息

概述
货号	MAB1154-SP
别名	AGE-R3; Carbohydrate-binding protein 35; CBP 35,35 kDa lectin; CBP35; GAL3; Gal-3; galactin-3; Galactose-specific lectin 3; Galactoside-binding protein; GALBPCBP35; galectin-3; GALIG; IgE-binding protein; L29; L31; L-31; Laminin-binding protein; Lectin L-29; lectin, galactoside-binding, soluble, 3; LGALS2; LGALS3; Mac-2 antigen; Mac-2; MAC2GAL3
反应种属	Human
应用	Western Blot
目标/特异性	Detects human Galectin-3 in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody shows 100% cross-reactivity with recombinant mouse Galectin-3 and no cross-reactivity with rhGalectin-1, -2 -4, -7, or -8.
使用方法	Western Blot: 0.2 µg/mL
来源	Reconstitute at 0.5 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3958 (Human); 16854 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. A role for collagen XXIII in cancer cell adhesion, anchorage-independence and metastasis. Authors: Spivey KA, Chung I, Banyard J Oncogene, 2012;31(18):2362-72. Species: Human Sample Type: Cell Lysates Application: WB Galectin-1-mediated cell death is increased by CD30-induced signaling in anaplastic large cell lymphoma cells but not in Hodgkin lymphoma cells. Authors: Suzuki O, Hirsch B, Abe M, Durkop H, Stein H Lab. Invest., 2012;92(2):191-9. Species: Human Sample Type: Cell Lysates Application: WB Galectin-3 is an amplifier of inflammation in atherosclerotic plaque progression through macrophage activation and monocyte chemoattraction. Authors: Papaspyridonos M, McNeill E, de Bono JP, Smith A, Burnand KG, Channon KM, Greaves DR Arterioscler. Thromb. Vasc. Biol., 2007;28(3):433-40. Species: Human Sample Type: Tissue Homogenates Application: WB
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	E. coli-derived recombinant human Galectin‑3 Ala2-Ile250 Accession # P17931
生物活性	Human
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	Galectin-3, also known as Mac-2, L29, CBP35 and epsilon BP, is a member of a large family of carbohydrate-binding proteins with specificity for N-acetyl-lactosamine-containing glycoproteins. At least 14 mammalian galectins, which share structural similarities in their carbohydrate recognition domains (CRD), have been identified to date. Galectin-3 is expressed in tumor cells, macrophages, activated T cells, osteoclasts, epithelial cells and fibroblasts.
运输条件	Blue Ice
存放说明	4℃
参考文献	A Role for Galectin-3 in Angiogenesis Airway Inflammation and Remodeling Cancer Biomarkers Common Macrophage Markers Endothelial Cell Markers and Adhesion Molecules in Angiogenesis Galectins Galectins (Article) ICC / IHC Images: Galectin-3 Lectins Mouse Tissue-Resident Macrophage Markers Myeloid-derived Suppressor Cells (MDSC) New Tools for Cancer Research: Cystatin C, Galectin-3, Rae-1 beta

参考图片

Detection of Human Galectin‑3 by Western Blot. Western blot shows lysates of COLO 205 human colorectal adenocarcinoma cell line, MCF‑7 human breast cancer cell line, and U‑118‑MG human glioblastoma/astrocytoma cell line. PVDF membrane was probed with 0.2 µg/mL of Mouse Anti-Human Galectin‑3 Monoclonal Antibody (Catalog # MAB1154) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF018). A specific band was detected for Galectin‑3 at approximately 28 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.