Mouse Rae-1 Pan Specific MAb (Clone 186107) (25 UG)【科瑞奥博】

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Mouse Rae-1 Pan Specific MAb (Clone 186107) (25 UG)

货号： MAB17582-SP 基本售价： 1467.3 元规格： -

产品信息

概述
货号	MAB17582-SP
别名	Rae1; Rae-1
全称	Retinoic Acid Early Transcript 1
反应种属	Mouse
应用	Flow Cytometry,CyTOF-ready
目标/特异性	Detects mouse Rae‑1. It recognizes Rae-1 alpha, beta, δ, gamma and epsilon.
使用方法	Flow Cytometry: 0.25 µg/10⁶cells
来源	Reconstitute at 0.5 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	8480 (Human); 19368 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. NKG2D-NKG2D Ligand Interaction Inhibits the Outgrowth of Naturally Arising Low-Grade B Cell Lymphoma In Vivo J Immunol, 2016;196(11):4805-13. Species: Mouse Sample Type: Whole Cells Application: Flow NKG2D-dependent activation of dendritic epidermal T cells in contact hypersensitivity. Authors: Nielsen M, Dyring-Andersen B, Schmidt J, Witherden D, Lovato P, Woetmann A, Odum N, Poulsen S, Havran W, Geisler C, Bonefeld C J Invest Dermatol, 2015;135(5):1311-9. Species: Mouse Sample Type: Homogenized Tissue Application: WB NKp46+ Innate Lymphoid Cells Dampen Vaginal CD8 T Cell Responses following Local Immunization with a Cholera Toxin-Based Vaccine. Authors: Luci C, Bekri S, Bihl F, Pini J, Bourdely P, Nouhen K, Malgogne A, Walzer T, Braud V, Anjuere F PLoS ONE, 2015;10(12):e0143224. Species: Mouse Sample Type: Whole Cells Application: Flow Engagement of NKG2D on bystander memory CD8 T cells promotes increased immunopathology following Leishmania major infection. Authors: Crosby E, Goldschmidt M, Wherry E, Scott P PLoS Pathog, 2014;10(2):e1003970. Species: Mouse Sample Type: Whole Cells Application: Flow RAE-1 ligands for the NKG2D receptor are regulated by E2F transcription factors, which control cell cycle entry. Authors: Jung, Heiyoun, Hsiung, Benjamin, Pestal, Kathleen, Procyk, Emily, Raulet, David H J Exp Med, 2012;209(13):2409-22. Species: Mouse Sample Type: whole cells Application: Flow Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease. Authors: Borchers MT, Wesselkamper SC, Curull V, Ramirez-Sarmiento A, Sanchez-Font A, Garcia-Aymerich J, Coronell C, Lloreta J, Agusti AG, Gea J, Howington JA, Reed MF, Starnes SL, Harris NL, Vitucci M, Eppert BL, Motz GT, Fogel K, McGraw DW, Tichelaar JW, Orozco-Levi M J. Clin. Invest., 2009;119(3):636-49. Species: Mouse Sample Type: Whole Cells Application: Flow Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance. Authors: Unni AM, Bondar T, Medzhitov R Proc. Natl. Acad. Sci. U.S.A., 2008;105(5):1686-91. Species: Mouse Sample Type: Whole Cells Application: Flow Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus. Authors: Vilarinho S, Ogasawara K, Nishimura S, Lanier LL, Baron JL Proc. Natl. Acad. Sci. U.S.A., 2007;104(46):18187-92. Species: Mouse Sample Type: Whole Cells Application: Flow Chimeric NKG2D receptor-bearing T cells as immunotherapy for ovarian cancer. Authors: Barber A, Zhang T, DeMars LR, Conejo-Garcia J, Roby KF, Sentman CL Cancer Res., 2007;67(10):5003-8. Species: Mouse Sample Type: Whole Cells Application: Flow A role for activation-induced cytidine deaminase in the host response against a transforming retrovirus. Authors: Gourzi P, Leonova T, Papavasiliou FN Immunity, 2006;24(6):779-86. Species: Mouse Sample Type: Whole Cells Application: Flow BCR/ABL promotes dendritic cell-mediated natural killer cell activation. Authors: Terme M, Borg C, Guilhot F, Masurier C, Flament C, Wagner EF, Caillat-Zucman S, Bernheim A, Turhan AG, Caignard A, Zitvogel L Cancer Res., 2005;65(14):6409-17. Species: Mouse Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Mouse myeloma cell line NS0-derived recombinant mouse Rae-1δ Leu29-Ser227 Accession # Q9JI58
生物活性	Mouse
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	Rae-1 alpha, beta, gamma, δ and epsilon comprise a family of closely related (88-95% amino acid identity) GPI-linked cell surface proteins that function as ligands for mouse NKG2D, an activating receptor expressed on NK and T cells. Rae-1 transcripts are expressed in mouse embryos and several tumor cell lines but are absent from most normal adult tissues. Rae-1 protein expression on tumor cell lines has been implicated in in vivo tumor rejection.
运输条件	Blue Ice
存放说明	4℃
参考文献	Mini-review: NKG2D and its Ligands Natural Killer T (NKT) Cells New Tools for Cancer Research: Cystatin C, Galectin-3, Rae-1 beta NKG2D Receptors and Ligands

参考图片

Detection of Rae‑1 in RAW 264.7 Mouse Cell Line by Flow Cytometry. RAW 264.7 mouse monocyte/macrophage cell line was stained with Rat Anti-Mouse Rae‑1 Pan Specific Monoclonal Antibody (Catalog # MAB17582, filled histogram) or isotype control antibody (Catalog # MAB006, open histogram), followed by Phycoerythrin-conjugated Anti-Rat IgG Secondary Antibody (Catalog # F0105B). View our protocol for Staining Membrane-associated Proteins.