Human/Bovine/Mouse Insulin MAb (Clone 182410) (25 UG)【科瑞奥博】

产品中心

当前位置：首页>产品中心

Human/Bovine/Mouse Insulin MAb (Clone 182410) (25 UG)

货号： MAB1417-SP 基本售价： 1467.3 元规格： -

产品信息

概述
货号	MAB1417-SP
别名	IDDM2; ILPR; INS; insulin; IRDN; MODY10; proinsulin
反应种属	Human/Bovine/Mouse
应用	CyTOF-ready,Immunocytochemistry,Intracellular Staining by Flow Cytometry
目标/特异性	Detects bovine, human, and mouse insulin.
使用方法	Immunocytochemistry: 8-25 µg/mL Intracellular Staining by Flow Cytometry: 2.5 µg/10⁶cells
来源	Reconstitute at 0.5 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3630 (Human); 16333 (Mouse); 397415 (Porcine); 280829 (Bovine); 483665 (Canine)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Accumulation of M1-like macrophages in type 2 diabetic islets is followed by a systemic shift in macrophage polarization. Authors: Cucak H, Grunnet L, Rosendahl A J Leukoc Biol, 2014;95(1):149-60. Species: Mouse Sample Type: whole cells Application: Flow Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes. Authors: Hagberg C, Mehlem A, Falkevall A, Muhl L, Fam B, Ortsater H, Scotney P, Nyqvist D, Samen E, Lu L, Stone-Elander S, Proietto J, Andrikopoulos S, Sjoholm A, Nash A, Eriksson U Nature, 2012;490(7420):426-30. Species: Mouse Sample Type: Whole Tissue Application: IHC Paraffin-embedded Beta-cell specific deletion of Dicer1 leads to defective insulin secretion and diabetes mellitus. Authors: Kalis M, Bolmeson C, Esguerra JL, Gupta S, Edlund A, Tormo-Badia N, Speidel D, Holmberg D, Mayans S, Khoo NK, Wendt A, Eliasson L, Cilio CM PLoS ONE, 2011;6(12):e29166. Species: Mouse Sample Type: Whole Cells Application: ICC Conversion of immortal liver progenitor cells into pancreatic endocrine progenitor cells by persistent expression of Pdx-1. Authors: Jin CX, Li WL, Xu F, Geng ZH, He ZY, Su J, Tao XR, Ding XY, Wang X, Hu YP J. Cell. Biochem., 2008;104(1):224-36. Species: Mouse Sample Type: Whole Cells Application: ICC Proteomic screening of glucose-responsive and glucose non-responsive MIN-6 beta cells reveals differential expression of proteins involved in protein folding, secretion and oxidative stress. Authors: Dowling P, O&amp;apos;Driscoll L, O&amp;apos;Sullivan F, Dowd A, Henry M, Jeppesen PB, Meleady P, Clynes M Proteomics, 2006;6(24):6578-87. Species: Mouse Sample Type: Whole Cells Application: ICC
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	E. coli-derived recombinant human Insulin
生物活性	Human, Mouse, Bovine
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	Insulin is a disulfide-linked heterodimeric protein secreted by the pancreatic Islets of Langerhans. Mature insulin is generated by the proteolytic removal of a peptide from proinsulin. It is involved in the regulation of glucose metabolism through interactions with the Insulin Receptor.
运输条件	Blue Ice
存放说明	4℃
参考文献	Cytokines in Lipid/Cholesterol Metabolism Diabetes Glucose Homeostasis Growth Hormone/IGF-I Axis ICC / IHC Images: Insulin IGF Family Interactive Pathway: Adipocytokines & Insulin Signaling Metabolism Nutrition and Appetite Pancreatic Endoderm Pancreatic Endoderm Cell Markers Preeclampsia Protein/Peptide Hormones and Regulators

参考图片

Insulin in beta TC‑6 Mouse Cell Line. Insulin was detected in immersion fixed beta TC‑6 mouse beta cell insulinoma cell line using Human/Mouse/Bovine Insulin Monoclonal Antibody (Catalog # MAB1417) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Rat IgG Secondary Antibody (red; Catalog # NL013) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.