| 货号 | MAB1229-SP |
| 别名 | a disintegrin and metalloproteinase domain 19 (meltrin beta); ADAM 19; ADAM metallopeptidase domain 19; disintegrin and metalloproteinase domain-containing protein 19; EC 3.4.24; EC 3.4.24.-; MADDAM; Meltrin beta; meltrin-beta; Metalloprotease and disintegrin dendritic antigen marker; MLTNBmeltrin beta | 全称 | A Disintegrin and Metalloprotease-like Domain 19 |
| 反应种属 | Mouse |
| 应用 | Western Blot |
| 目标/特异性 | Detects mouse ADAM19 Ectodomain in direct ELISAs and Western blots. It also recognizes a C-terminal fragment (amino acids 588‑705) of recombinant mouse (rm) ADAM19 in Western blots. In Western blots, no cross-reactivity with rmADAM10 or rmADAM15 is observed. |
| 使用方法 | Western Blot: 1 µg/mL |
| 来源 | Reconstitute at 0.5 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 8728 (Human); 11492 (Mouse) |
| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse ADAM19 Ectodomain Asp205-Gly705 (predicted) Accession # O35674 |
| 生物活性 | Mouse |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.5 mg/mL in sterile PBS. |
| 背景 | ADAM19 (a disintegrin and metalloprotease 19; also MADDAM and Meltrin-beta ) is a 95‑100 kDa member of the M12B peptidase family of enzymes. It is expressed on multiple cell types including monocytes, fibroblasts, osteoblasts and dendritic cells. After cleavage of a signal sequence and prodomain, the ectodomain circulates in plasma bound to alpha 2-Macroglobulin. ADAM19 cleaves at sequences present inmyelin basic protein, insulin beta chain, TNF-alpha, TRANCE and SCF. Over amino acids (aa) 205‑705, mouse ADAM19 shares 87% aa sequence identity with human ADAM19. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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