Mouse TSLP MAb (Clone 152614) (25 UG)【科瑞奥博】

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Mouse TSLP MAb (Clone 152614) (25 UG)

货号： MAB555-SP 基本售价： 1467.3 元规格： -

产品信息

概述
货号	MAB555-SP
别名	thymic stromal lymphopoietin
全称	Thymic Stromal Lymphopoietin
反应种属	Mouse
应用	Western Blot,Neutralization
目标/特异性	Detects mouse TSLP in Western blots.
使用方法	Western Blot: 1 µg/mL Neutralization: Measured by its ability to neutralize TSLP-induced proliferation in the BaF3 mouse pro‑B cell line transfected with mouse IL‑7 R alpha. Park, L.S. et al. (2000) J. Exp. Med. 192:659. The Neutralization Dose (ND₅₀) is typically 0.1‑0.4 µg/mL in the presence of 7.5 ng/mL Recombinant Mouse TSLP.
来源	Monoclonal Rat IgG_2A Clone # 152614
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	85480 (Human); 53603 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Thymic Stromal Lymphopoietin Neutralization Inhibits the Immune Adjuvant Effect of Di-(2-Ethylhexyl) Phthalate in Balb/c Mouse Asthma Model PLoS ONE, 2016;11(7):e0159479. Species: Mouse Sample Type: In Vivo Application: Neut Conditional PDK1 Ablation Promotes Epidermal and T-Cell-Mediated Dysfunctions Leading to Inflammatory Skin Disease. Authors: Yu M, Owens D, Ghosh S, Farber D J Invest Dermatol, 2015;135(11):2688-96. Species: Mouse Sample Type: Whole Tissue Application: IHC OCT-embedded Peroxisome proliferator-activated receptor gamma-mediated suppression of dendritic cell function prevents the onset of atopic dermatitis in NC/Tnd mice. Authors: Jung K, Tanaka A, Fujita H, Matsuda A, Oida K, Karasawa K, Okamoto N, Ohmori K, Jee Y, Shin T, Matsuda H J. Allergy Clin. Immunol., 2011;127(2):420-29. Species: Mouse Sample Type: Whole Cells Application: ICC IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin. Authors: Oh MH, Oh SY, Yu J J. Immunol., 2011;186(12):7232-42. Species: Mouse Sample Type: In Vivo Application: In vivo Thymic stromal lymphopoietin is a key mediator of breast cancer progression. Authors: Olkhanud PB, Rochman Y, Bodogai M J. Immunol., 2011;186(10):5656-62. Species: Mouse Sample Type: In Vivo Application: In vivo Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic inflammation. Authors: Miyata M, Nakamura Y, Shimokawa N, Ohnuma Y, Katoh R, Matsuoka S, Okumura K, Ogawa H, Masuyama K, Nakao A Eur. J. Immunol., 2009;39(11):3078-83. Species: Mouse Sample Type: In Vivo Application: In vivo A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation. Authors: Boehme SA, Franz-Bacon K, Chen EP, Sasik R, Sprague LJ, Ly TW, Hardiman G, Bacon KB Int. Immunol., 2009;21(1):81-93. Species: Mouse Sample Type: In Vivo Application: In vivo A mechanism for the initiation of allergen-induced T helper type 2 responses. Authors: Sokol CL, Barton GM, Farr AG, Medzhitov R Nat. Immunol., 2008;9(3):310-8. Species: Mouse Sample Type: Whole Cells Application: Flow Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells. Authors: Zhu J, Garrett R, Jung Y, Zhang Y, Kim N, Wang J, Joe GJ, Hexner E, Choi Y, Taichman RS, Emerson SG Blood, 2007;109(9):3706-12. Species: Mouse Sample Type: Whole Cells Application: Neut
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse TSLP Tyr20-Glu140 Accession # Q9JIE6
内毒素水平	<0.10 EU per 1 μg of the antibody by the LAL method.
生物活性	Mouse
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	TSLP is an IL-7 related cytokine secreted by multiple tissues. Itinteracts with the heterodimeric receptor complex consisting of IL-7 R alpha and TSLP R. Mouse TSLP stimulates the growth of thymocytes and mature Tcells and also supports B cell lymphopoiesis.
运输条件	Blue Ice
存放说明	4℃
参考文献	B Cell Development and Differentiation Cytokines and Receptors in Allergy and Asthma Group 2 ILCs Multiple Sclerosis and Myelin Related Molecules Regulatory T Cells (Tregs) Th2 Cells TSLP, Inflammation, & Cancer

参考图片

Cell Proliferation Induced by TSLP and Neutralization by Mouse TSLP Antibody. Recombinant Mouse TSLP (Catalog # 555-TS) stimulates proliferation in the BaF3 mouse pro‑B cell line transfected with mouse IL‑7 R alpha in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse TSLP (7.5 ng/mL) is neutralized (green line) by increasing concentrations of Mouse TSLP Monoclonal Antibody (Catalog # MAB555). The ND₅₀ is typically 0.1-0.4 µg/mL.