Human BAFF/BLyS/TNFSF13B MAb (Clone 148725) (25 UG)【科瑞奥博】

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Human BAFF/BLyS/TNFSF13B MAb (Clone 148725) (25 UG)

货号： MAB124-SP 基本售价： 1467.3 元规格： -

产品信息

概述
货号	MAB124-SP
别名	ApoL related ligand TALL-1; B lymphocyte stimulator; BAFFB-cell activating factor; B-cell-activating factor; BLyS; BLYSB-lymphocyte stimulator; CD257 antigen; CD257; Dendritic cell-derived TNF-like molecule; DTL; TALL1; TALL-1delta BAFF; TALL1Delta4 BAFF; THANK; TNF- and APOL-related leukocyte expressed ligand 1; TNF and ApoL-related leukocyte expressed ligand 1; TNF homolog that activates apoptosis; TNFSF13B; TNFSF20; tumor necrosis factor (ligand) superfamily, member 13b; tumor necrosis factor (ligand) superfamily, member 20; tumor necrosis factor ligand superfamily member 13B; tumor necrosis factor superfamily, member 13b; tumor necrosis factor-like protein ZTNF4; ZTNF4
全称	B cell Activating Factor
反应种属	Human
应用	Neutralization
目标/特异性	Detects human BAFF in direct ELISAs.
使用方法	Neutralization: Measured by its ability to neutralize BAFF/BLyS/TNFSF13B-induced proliferation in mouse B cells. At 20 µg/mL, this anti-BAFF/BLyS/TNFSF13B antibody will neutralize > 60% of 5 ng/mL Recombinant Human BAFF/BLyS/TNFSF13B-induced proliferation of mouse B cells.
来源	Monoclonal Mouse IgG_2B Clone # 148725
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	10673 (Human); 24099 (Mouse); 498666 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. IFN-beta therapy modulates B-cell and monocyte crosstalk via TLR7 in multiple sclerosis patients. Authors: Giacomini E, Severa M, Rizzo F, Mechelli R, Annibali V, Ristori G, Riccieri V, Salvetti M, Coccia E Eur J Immunol, 2013;43(7):1963-72. Species: Human Sample Type: whole cells Application: Neut IL-15 Expression on RA Synovial Fibroblasts Promotes B Cell Survival. Authors: Benito-Miguel M, Garcia-Carmona Y, Balsa A, Bautista-Caro MB, Arroyo-Villa I, Cobo-Ibanez T, Bonilla-Hernan MG, De Ayala CP, Sanchez-Mateos P, Martin-Mola E, Miranda-Carus ME PLoS ONE, 2012;7(7):e40620. Species: Human Sample Type: Whole Cells Application: Flow Constitutive NF-kappaB and NFAT activation leads to stimulation of the BLyS survival pathway in aggressive B-cell lymphomas. Authors: Fu L, Lin-Lee YC, Pham LV, Tamayo A, Yoshimura L, Ford RJ Blood, 2006;107(11):4540-8. Species: Human Sample Type: Whole Cells Application: ICC
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Mouse myeloma cell line NS0-derived recombinant human BAFF Ala134-Leu285 Accession # Q9Y275
内毒素水平	<0.10 EU per 1 μg of the antibody by the LAL method.
生物活性	Human
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	BAFF, also known as B-lymphocyte stimulator (BLyS), TNF- andAPOL-related leukocyte expressed ligand 1 (TALL-1), and TNF homologthat activates apoptosis, NFKB and JNK (THANK), is a TNF ligandsuperfamily member and has been designated TNFSF13B.
运输条件	Blue Ice
存放说明	4℃
参考文献	BAFF and APRIL Involvement in B Cell Development Co-stimulatory and Co-inhibitory Molecules Human CD Marker Products ICC / IHC Images: BAFF/BLyS/TNFSF13B Regulation of Apoptosis by TNF Superfamily Members Regulation of B Cell Activation and Homeostasis by TNF Superfamily Members Regulation of T Cell Co-stimulation by TNF Superfamily Members TNF Homologue Implicated in Systemic Lupus Erythematosus (SLE) TNF Superfamily TNF Superfamily Ligands

参考图片

Cell Proliferation Induced by BAFF/BLyS/TNFSF13B and Neutralization by Human BAFF/BLyS/TNFSF13B Antibody. Recombinant Human BAFF/BLyS/TNFSF13B (Catalog # 2149-BF) stimulates proliferation in mouse B cells in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human BAFF/BLyS/TNFSF13B (5 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human BAFF/BLyS/TNFSF13B Monoclonal Antibody (Catalog # MAB124). At 20 µg/mL, this anti-BAFF/BLyS/TNFSF13B antibody will neutralize 60% of Recombinant Human BAFF/BLyS/TNFSF13B-induced proliferation of mouse B cells.