| 货号 | MAB8629-SP |
| 简介 | Recombinant Monoclonal Antibody |
| 别名 | hMOP; KIAA0403; LMOR; MOP; MOR; MOR1; M-OR-1; MOR-1; MOR1MOR; Mu opiate receptor; Mu opioid receptor; mu-type opioid receptor; opioid receptor, mu 1; OPRM; OPRM1 | 全称 | mu Opioid Receptor |
| 反应种属 | Rat |
| 应用 | Immunohistochemistry |
| 目标/特异性 | Detects rat μ Opioid R/OPRM1 in direct ELISAs. |
| 使用方法 | Immunohistochemistry: 1:125 dilution |
| 来源 | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 4988 (Human); 18390 (Mouse); 25601 (Rat) |
| 纯化方式 | Protein A or G purified from cell culture supernatant |
| 免疫原 | Synthetic peptide with a short amino acid sequence from the N-terminus of rat μ Opioid R/OPRM1 Accession # P33535 |
| 生物活性 | Rat |
| 标记 | Unconjugated |
| 背景 | The mu-type opioid receptor (MOR), also known as OPRM1, is a 60‑70 kDa variably glycosylated G protein-coupled receptor that mediates the biological effects of many alkaloid and peptide opioids including morphine. MOR is primarily expressed on neurons in the brain, spinal cord, and gastrointestinal tract as well as on immune cells. MOR activation induces analgesia, euphoria, sedation, respiratory depression, and reduced intestinal motility. Following agonist binding, MOR is phosphorylated and internalized which contributes to opioid tolerance and desensitization. OPRM1 can form heterdimers with several other 7TM GPCRs including the delta-type Opioid Receptor (DOR), Nociceptin/Orphanin Receptor (ORL1), Neurokinin 1 Receptor (NK1), Somatostatin Receptor 2 (SSTR2), Cannabinoid Receptor 1, CCR5, and the alpha 2A-Adrenergic Receptor (ADRA2A). Rat MOR shares 94% and 98% aa sequence identity with human and mouse MOR, respectively. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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μ Opioid R/OPRM1 in Rat Spinal Cord. μ Opioid R/OPRM1 was detected in perfusion fixed frozen sections of rat spinal cord using Rabbit Anti-Rat μ Opioid R/OPRM1 Monoclonal Antibody (Catalog # MAB8629) at 1:125 dilution overnight at 4 °C. Tissue was stained using the NorthernLights™ 557-conjugated Anti-Rabbit IgG Secondary Antibody (red; Catalog # NL004) and counterstained with DAPI (blue). Specific staining was localized to dorsal horn. View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections. |
