Human MMP-3 MAb (Clone 10D6) (25 UG)【科瑞奥博】

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Human MMP-3 MAb (Clone 10D6) (25 UG)

货号： MAB905-SP 基本售价： 1467.3 元规格： -

产品信息

概述
货号	MAB905-SP
别名	CHDS6; EC 3.4.24; EC 3.4.24.17; matrix metallopeptidase 3 (stromelysin 1, progelatinase); matrix metalloproteinase 3 (stromelysin 1, progelatinase); Matrix metalloproteinase-3; MGC126102; MGC126103; MMP-3; proteoglycanase; SL-1; STMY; STMY1MGC126104; STR1; Stromelysin 1; stromelysin-1; transin-1
全称	Matrix Metalloproteinase 3
反应种属	Human
应用	Western Blot,Immunohistochemistry,Immunoprecipitation
目标/特异性	Detects the pro and active forms of human MMP-3 in Western blots. In Western blots, no cross-reactivity with recombinant human (rh) MMP‑1, rhMMP-2 or rhMMP-9 is observed.
使用方法	Western Blot: 1 µg/mL Immunohistochemistry: 8-25 µg/mL Immunoprecipitation: 25 µg/mL
来源	Reconstitute at 0.5 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	4314 (Human); 17392 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Matrix metalloproteinase activity in pediatric acute lung injury. Authors: Kong MY, Gaggar A, Li Y Int J Med Sci, 2009;6(1):9-17. Species: Human Sample Type: Endotracheal aspirate Application: WB Gingival fibroblasts inhibit MMP-1 and MMP-3 activities in an ex-vivo artery model. Authors: Naveau A, Reinald N, Fournier B Connect. Tissue Res., 2007;48(6):300-8. Species: Human Sample Type: Whole Cells Application: DB
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	Chinese hamster ovary cell line CHO-derived recombinant human MMP-3
生物活性	Human
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-3 (stromelysin-1), can degrade a broad range of substrates including collagen alpha chains, aggrecan, laminin, fibronectin, elastin, casein, alpha -1 antitrypsin, myelin basic protein, IL-1 beta, IGFBP-3, pro MMP-1, pro MMP-7, pro MMP-8, pro MMP-9 and pro MMP-13. MMP-3 does not cleave the triple helical region of interstitial collagens, a characteristic which distinguishes the stromelysins from the collagenases. The MMP-3 substrate repertoire extends beyond extracellular matrix proteins and implicates MMP-3 in roles other than direct tissue remodelling, for instance, enzyme cascades and cytokine regulation. MMP-3 is expressed by fibroblasts, chrondrocytes, osteoblasts, endothelial cells, smooth muscle cells and macrophages. Structurally, MMP-3 may be divided into several distinct domains; a pro-domain which is cleaved upon activation; a catalytic domain containing the zinc binding site; a short hinge region and a carboxyl terminal (hemopexin-like) domain.
运输条件	Blue Ice
存放说明	4℃
参考文献	Cancer Biomarkers Cell to Cell Adhesion Disassembly During EMT Collagen Modifying Enzymes EMT Induction Extracellular Matrix Remodeling and Cell Migration During EMT ICC / IHC Images: MMP-3 Mesenchymal Cells and EMT Metalloproteases and Regulators MMP Modulation of Cytokines MMP-12 in Smoking-Related Pulmonary Disease MMPs, TIMPs and Related Molecules New Tools: Active MMP Activity Assays OSM Induction of Chondrocyte MMP and TIMP-3 Gene Expression

参考图片

MMP‑3 in Human Ovarian Cancer Tissue. MMP‑3 was detected in immersion fixed paraffin-embedded sections of human ovarian cancer tissue using 25 µg/mL Mouse Anti-Human MMP‑3 Monoclonal Antibody (Catalog # MAB905) overnight at 4 °C. Tissue was stained with the Anti-Mouse HRP-AEC Cell & Tissue Staining Kit (red; Catalog # CTS003) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.