Mouse IL-17 RA/IL-17 R MAb (Clone 105828) (25 UG)【科瑞奥博】

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Mouse IL-17 RA/IL-17 R MAb (Clone 105828) (25 UG)

货号： MAB448-SP 基本售价： 1467.3 元规格： -

产品信息

概述
货号	MAB448-SP
别名	CD217 antigen; CD217; Cdw217; CDw217interleukin 17 receptor; hIL-17R; IL-17 R; IL-17 receptor A; IL17RA; IL-17RAMGC10262; IL17Rinterleukin-17 receptor A; interleukin 17 receptor A
全称	Interleukin 17 Receptor
反应种属	Mouse
应用	Western Blot
目标/特异性	Detects mouse IL‑17 RA/IL‑17 R in direct ELISAs and Western blots. Shows 50-100% cross‑reactivity with recombinant human IL-17 RA/IL-17 R and no cross‑reactivity with recombinant mouse IL-17B R.
使用方法	Western Blot: 2 µg/mL
来源	Reconstitute at 0.5 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	23765 (Human); 16172 (Mouse); 312679 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Production and functions of IL-17 in microglia. Authors: Kawanokuchi J, Shimizu K, Nitta A, Yamada K, Mizuno T, Takeuchi H, Suzumura A J. Neuroimmunol., 2007;194(1):54-61. Species: Mouse Sample Type: Cell Lysates Application: WB
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse IL‑17 RA/IL‑17 R Extracellular domain Accession # Q60943
生物活性	Mouse
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	IL-17 R, also knownas IL-17 RA, is a widely expressed 120 kDa glycosylated type I protein thatplays a central role in inflammatory responses. IL-17 R associates with IL-17RC to form a signaling receptor complex for IL-17 and IL-17F. IL-17 R ligationpromotes T cell activation and the production of IL-6, G-CSF, SCF, and multipleproinflammatory chemokines. Within the ECD, human IL-17 R shares 72% aasequence identity with mouse and rat IL-17 R.
运输条件	Blue Ice
存放说明	4℃
参考文献	Cytokines and Receptors in Tfh Cell Differentiation and Function Human CD Marker Products IL-17 Family Mini-review: Interleukin 17 (IL-17) Multiple Sclerosis and Myelin Related Molecules Th17 Cells Th2 Cells Th9 Cells

参考图片

Detection of Mouse IL‑17 RA/IL‑17 R by Western Blot.

Western blot shows lysates of RAW 264.7 mouse monocyte/macrophage cell line. PVDF membrane was probed with 2 µg/mL of Rat Anti-Mouse IL‑17 RA/IL‑17 R Monoclonal Antibody (Catalog # MAB448) followed by HRP-conjugated Anti-Rat IgG Secondary Antibody (Catalog # HAF005). A specific band was detected for IL‑17 RA/IL‑17 R at approximately 150 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.