Human Presenilin-1 N-Term MAb (Clone 121121) (25 UG)【科瑞奥博】

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Human Presenilin-1 N-Term MAb (Clone 121121) (25 UG)

货号： MAB149-SP 基本售价： 1467.3 元规格： -

产品信息

概述
货号	MAB149-SP
别名	AD3EC 3.4.23.-; Alzheimer disease 3; EC 3.4.23; FAD; presenilin 1; Protein S182; PS-1; PS1presenilin-1; PSEN1; PSNL1; S182
反应种属	Human
应用	Western Blot,Immunohistochemistry
目标/特异性	Detects human Presenilin‑1 N-Terminal Fragment in direct ELISAs and Western blots. Does not cross-react with recombinant human (rh) Presenilin‑2 N-Terminal Fragment, rhPresenilin‑1 C-Terminal Fragment, or rhPresenilin‑2 C-Terminal Fragment.
使用方法	Western Blot: 1 µg/mL Immunohistochemistry: 1-25 µg/mL
来源	Reconstitute at 0.5 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	5663 (Human)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis. Authors: Siegemund S, Schutze N, Schulz S, Wolk K, Nasilowska K, Straubinger RK, Sabat R, Alber G Int. Immunol., 2009;21(5):555-65. Species: Mouse Sample Type: Cell Culture Supernates Application: ELISA Development
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	E. coli-derived recombinant human Presenilin‑1 N-Terminal Fragment Lys1-Lys80 Accession # P49768
生物活性	Human
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	Presenilin‑1 (PS-1) is a multipass lysosomal membrane protein that is a component of the gamma secretase complex. It is cleaved by endoproteolysis to generate N‑ and C‑terminal fragments. Some mutations in PS-1 are associated with the risk of early onset familial Alzheimers disease.
运输条件	Blue Ice
存放说明	4℃
参考文献	APP Cleavage and Amyloid-beta Degradation Aspartic Proteases and Regulators Cell to Cell Adhesion Disassembly During EMT ICC / IHC Images: Presenilin-1 Mini-review: Alzheimers Disease Neurodegenerative Disease Notch Family Notch Pathway

参考图片

Presenilin‑1 in Human Brain. Presenilin‑1 was detected in immersion fixed paraffin-embedded sections of human brain (medulla) using Mouse Anti-Human Presenilin‑1 N-Terminal Fragment Monoclonal Antibody (Catalog # MAB149) at 1.7 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Mouse IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC001). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to neuronal cell bodies. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.