| 货号 | MAB3871-SP |
| 别名 | neurturin; NRTN; NTN |
| 反应种属 | Human |
| 应用 | Western Blot,Blockade of Receptor-ligand Interaction |
| 目标/特异性 | Detects human Neurturin in direct ELISAs and Western blots. In sandwich immunoassays, no cross-reactivity with recombinant mouse Neurturin, recombinant human (rh) TGF-alpha, rhTGF-beta 2, rhTGF-beta 1.2, rhTGF-beta 3, rhGDNF, rhLAP, or recombinant rat TGF-beta 5 is observed. |
| 使用方法 | Western Blot: 1 µg/mL Blockade of Receptor-ligand Interaction: In a functional ELISA, 0.06-0.3 µg/mL of this antibody will block 50% of the binding of 50 ng/mL of Recombinant Human Neurturin (Catalog # 1297-NE) to immobilized Recombinant Human GFR alpha -2 Fc Chimera (Catalog # 613‑FR) coated at 1 µg/mL (100 µL/well). At 5 μg/mL, this antibody will block >90% of the binding. |
| 来源 | Monoclonal Mouse IgG1 Clone # 126424 |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 4902 (Human); 18188 (Mouse) |
| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | E. coli-derived recombinant human Neurturin Ala96-Val197 Accession # Q99748 |
| 内毒素水平 | <0.10 EU per 1 μg of the antibody by the LAL method. |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.5 mg/mL in sterile PBS. |
| 背景 | Neurturin is a member of the GDNF family of ligands and is distantlyrelated to TGF-beta family ligands. It is a disulfide-linked homodimerthat interacts with a receptor complex composed of a high affinityligand binding component (GFR alpha 1 or GFR alpha 2) and a common signalingcomponent, cRET. Neurturin promotes the survival of a variety ofneurons and possibly other cell types. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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