Human NKG2C MAb (Clone 134522) (25 UG)【科瑞奥博】

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Human NKG2C MAb (Clone 134522) (25 UG)

货号： MAB1381-SP 基本售价： 1467.3 元规格： -

产品信息

概述
货号	MAB1381-SP
别名	CD159 antigen-like family member C; CD159c antigen; CD159c; killer cell lectin-like receptor subfamily C, member 2; KLRC2; MGC138244; NK cell receptor C; NKG2-C type II integral membrane protein; NKG2-C; NKG2CNKG2-C-activating NK receptor
全称	Natural Killer G2C
反应种属	Human
应用	Flow Cytometry,CyTOF-reported
目标/特异性	Detects human NKG2C/CD159c. Detects human NKG2C/CD159c as part of the NKG2C/CD94 heterodimer in flow cytometry. No cross-reactivity with the human NKG2A/CD94 heterodimer or with the human CD94 homodimer is detected.
使用方法	Flow Cytometry: 0.25 µg/10⁶cells
来源	Reconstitute at 0.5 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3822 (Human)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. NK Cell Proliferation Induced by IL-15 Transpresentation Is Negatively Regulated by Inhibitory Receptors. Authors: Anton O, Vielkind S, Peterson M, Tagaya Y, Long E J Immunol, 2015;195(10):4810-21. Species: Human Sample Type: Whole Cells Application: Flow Antibody-mediated response of NKG2Cbright NK cells against human cytomegalovirus. Authors: Costa-Garcia M, Vera A, Moraru M, Vilches C, Lopez-Botet M, Muntasell A J Immunol, 2015;194(6):2715-24. Species: Human Sample Type: Whole Cells Application: Flow Regulation of Adaptive NK Cells and CD8 T Cells by HLA-C Correlates with Allogeneic Hematopoietic Cell Transplantation and with Cytomegalovirus Reactivation. Authors: Horowitz A, Guethlein L, Nemat-Gorgani N, Norman P, Cooley S, Miller J, Parham P J Immunol, 2015;195(9):4524-36. Species: Human Sample Type: Whole Cells Application: CyTof Autologous antitumor activity by NK cells expanded from myeloma patients using GMP-compliant components. Authors: Alici E, Sutlu T, Bjorkstrand B, Gilljam M, Stellan B, Nahi H, Quezada HC, Gahrton G, Ljunggren HG, Dilber MS Blood, 2008;111(6):3155-62. Species: Human Sample Type: Whole Cells Application: Neut Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation. Authors: Coupel S, Moreau A, Hamidou M, Horejsi V, Soulillou JP, Charreau B Blood, 2007;109(7):2806-14. Species: Human Sample Type: Whole Cells Application: Neut
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	BaF3 mouse pro-B cell line transfected with human NKG2C/CD159c and CD94
内毒素水平	<0.10 EU per 1 μg of the antibody by the LAL method.
生物活性	Human
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	NKG2C, also known as hemoglobin scavenger receptor, is a type I transmembrane protein expressed exclusively in monocytes and macrophages. It is a scavenger receptor cysteine-rich superfamily (SRCR-SF) protein that contains nine SRCR motifs in its extracellular region. MAB1381 displays potent agonistic activity and also blocks the binding of the NKG2C/CD94 heterodimer to HLA-E tetramers (1-3).
运输条件	Blue Ice
存放说明	4℃
参考文献	Alici, E. et al. (2008) Blood 111:3155. Coupel, S. et al. (2007) Blood 109:2806. Fausther-Bovendo, H. et al. (2008) AIDS 22:217.

参考图片

Detection of NKG2C/CD159c in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human NCAM‑1/CD56 APC‑conjugated Monoclonal Antibody (Catalog # FAB2408A) and either (A) Mouse Anti-Human NKG2C/CD159c Monoclonal Antibody (Catalog # MAB1381) or (B) Mouse IgG_2B Flow Cytometry Isotype Control (Catalog # MAB0041) followed by Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B). View our protocol for Staining Membrane-associated Proteins.