| 货号 | MAB1058-SP |
| 别名 | CD94 antigen; CD94; CD94natural killer cells antigen CD94; Killer cell lectin-like receptor subfamily D member 1; killer cell lectin-like receptor subfamily D, member 1; KLRD1; KP43; NK cell receptor |
| 反应种属 | Human |
| 应用 | Flow Cytometry,Blockade of Receptor-ligand Interaction,CyTOF-ready |
| 目标/特异性 | Recognizes human CD94 both in its homodimeric form and as a heterodimer with either NKG2A or NKG2C. |
| 使用方法 | Flow Cytometry: 0.25 µg/106cells Blockade of Receptor-ligand Interaction: HLA-E tetramers at 3 μg/mL were incubated with BaF/3 cells transfected with hNKG2C/CD94, and binding was monitored by flow cytometry. A 15 minute pre-incubation of the transfected cells with this antibody at a concentration of 17 μg/mL inhibited 95% of the HLA-E tetramer binding. |
| 来源 | Monoclonal Mouse IgG1 Clone # 131412 |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 3824 (Human) |
| 应用文献 | |
| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. MicroRNA editing facilitates immune elimination of HCMV infected cells. | |
| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | BaF3 mouse pro-B cell line transfected with human CD94 and NKG2A |
| 内毒素水平 | <0.10 EU per 1 μg of the antibody by the LAL method. |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.5 mg/mL in sterile PBS. |
| 背景 | The type-II transmembrane glycoprotein CD94 covalently associates with C-type lectins of the NKG2 family to yield heterodimers important in NK cell recognition of class I MHC molecules. CD94/NKG2A complexes are also found on a subset of CD8+ T cells. Expression of CD94/NKG2 heterodimers may regulate cell survival and effector functions. There are two alternatively spliced variants of CD94 that differ by 31 amino acids encoded by exon 2. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 参考文献 |
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