Phospho-Smad2 (Ser465/467) (138D4) Rabbit mAb
货号：
3108L 基本售价：
9380.0 元 规格：
-
产品信息
概述| 货号 | 3108L |
| 反应种属 | Human/Mouse/Rat/Mink |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-Smad2 (Ser465/467) (138D4) Rabbit mAb detects endogenous levels of Smad2 only when dually phosphorylated at serines 465 and 467, and may detect Smad3 phosphorylated at the equivalent sites. This antibody does not cross-react with other Smad-related proteins. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Members of the Smad family of signal transduction molecules are components of a critical intracellular pathway that transmit TGF-β signals from the cell surface into the nucleus. Three distinct classes of Smads have been defined: the receptor-regulated Smads (R-Smads), which include Smad1, 2, 3, 5, and 8; the common-mediator Smad (co-Smad), Smad4; and the antagonistic or inhibitory Smads (I-Smads), Smad6 and 7 (1-5). Activated type I receptors associate with specific R-Smads and phosphorylate them on a conserved carboxy terminal SSXS motif. The phosphorylated R-Smad dissociates from the receptor and forms a heteromeric complex with the co-Smad (Smad4), allowing translocation of the complex to the nucleus. Once in the nucleus, Smads can target a variety of DNA binding proteins to regulate transcriptional responses (6-8). |
| 存放说明 | -20C |
| 计算分子量 | 60 |
参考图片Western blot analysis of extracts from untreated or TGF-beta treated HeLa and NIH/3T3 cells, using Phospho-Smad2 (Ser465/467) (138D4) Rabbit mAb (upper), or Smad2 Antibody #3102 (lower). 使用 Phospho-Smad2 (Ser465/467) (138D4) Rabbit mAb兔单抗（上）或Smad2抗体#3102（下）对未处理或经过TGF-beta 处理的HeLa和NIH/3T3 细胞提取物进行western blot分析。 |
