| 货号 | 2338L |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IHC-P/F |
| 使用方法 | WB(1:2000) IHC-P (1:50) F (1:100) |
| 供应商 | CST |
| 背景 | MEK1 and MEK2, also called MAPK or Erk kinases, are dual-specificity protein kinases that function in a mitogen activated protein kinase cascade controlling cell growth and differentiation (1-3). Activation of MEK1 and MEK2 occurs through phosphorylation of two serine residues at positions 217 and 221, located in the activation loop of subdomain VIII, by Raf-like molecules. MEK1/2 is activated by a wide variety of growth factors and cytokines and also by membrane depolarization and calcium influx (1-4). Constitutively active forms of MEK1/2 are sufficient for the transformation of NIH/3T3 cells or the differentiation of PC-12 cells (4). MEK activates p44 and p42 MAP kinase by phosphorylating both threonine and tyrosine residues at sites located within the activation loop of kinase subdomain VIII. |
| 存放说明 | -20C |
| 计算分子量 | 45 |
Immunohistochemical analysis of paraffin-embedded human lung carcinoma, using Phospho-MEK1/2 (Ser221) (166F8) Rabbit mAb. | |
使用Phospho-MEK1/2 (Ser221)(166F8) Rabbit mAb兔单抗，对石蜡包埋的人乳腺癌组织进行免疫组织化学检测。 | |
Immunohistochemical analysis of paraffin-embedded prostate carcinoma, untreated (left) or lambda phosphatase-treated (right), using Phospho-MEK1/2 (Ser221) (166F8) Rabbit mAb. | |
使用Phospho-MEK1/2 (Ser221) (166F8) Rabbit mAb兔单抗，对未处理的（左）或用lambda磷酸酶处理的（右）的石蜡包埋的人前列腺癌组织进行免疫组织化学检测。 | |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma, using Phospho-MEK1/2 (Ser221)(166F8) Rabbit mAb. | |
使用Phospho-MEK1/2 (Ser221)(166F8) Rabbit mAb兔单抗，对石蜡包埋的人乳腺癌组织进行免疫组织化学方法检测。 |
