Phospho-PERK (Thr980) (16F8) Rabbit mAb
货号：
3179L 基本售价：
9300.0 元 规格：
-
产品信息
概述| 货号 | 3179L |
| 反应种属 | Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-PERK (Thr980) (16F8) Rabbit mAb detects endogenous levels of PERK phosphorylated at Thr980. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | PERK (protein kinase-like endoplasmic reticulum kinase) is an eIF2α kinase and transmembrane protein resident in the endoplasmic reticulum (ER) membrane that couples ER stress signals to translation inhibition (1-3). ER stress increases the activity of PERK, which then phosphorylates eIF2α to promote reduced translation. PERK-deficient mice have defects in pancreatic β cells several weeks after birth, suggesting a role for PERK-mediated translational control in protecting secretory cells from ER stress (4). PERK activation during ER stress correlates with autophosphorylation of its cytoplasmic kinase domain (1-3). Phosphorylation of PERK at Thr980 serves as a marker for its activation status. |
| 存放说明 | -20C |
| 计算分子量 | 170 |
参考图片Western blot analysis of extracts from AR42J cells untreated (-) or treated with 1 μM thapsigargin (Tg) for 20 minutes (+), using Phospho-PERK (Thr980) (16F8) Rabbit mAb. 对AR42J细胞（未处理(-)，或1uM thapsigargin (Tg) (+) 处理20分钟），使用Phospho-PERK (Thr980) (16F8) Rabbit mAb兔单抗进行Western blot分析。 |
