| 货号 | 9197L |
| 反应种属 | Human/Mouse/Rat/Monkey/D.melanogaster |
| 来源宿主 | Rabbit |
| 应用 | W/IP/IHC-P/IHC-F/IF-F/IF-IC/F/ChIP |
| 目标/特异性 | CREB (48H2) Rabbit mAb detects endogenous levels of total CREB protein. |
| 使用方法 | WB(1:1000) IP (1:250) IHC-P (1:6400) F (1:400) IF-F (1:800) IF-IC (1:800) IHC-F (1:6400) ChIP (1:50) |
| 供应商 | CST |
| 背景 | CREB is a bZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth, and neuronal differentiation in certain neuronal populations (1-3). Additionally, CREB signaling is involved in learning and memory in several organisms (4-6). CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+, and stress signaling. Some of the kinases involved in phosphorylating CREB at Ser133 are p90RSK, MSK, CaMKIV, and MAPKAPK-2 (7-9). |
| 存放说明 | -20C |
| 计算分子量 | 43 |
Immunohistochemical analysis of paraffin-embedded human lung carcinoma, using CREB (48H2) Rabbit mAb. 免疫组化分析石蜡包埋的人肺癌，使用的抗体是CREB (48H2) Rabbit mAb 兔单抗。 | |
Immunohistochemical analysis of paraffin-embedded human Non-Hodgkins lymphoma, using CREB (48H2) Rabbit mAb. 免疫组化分析石蜡包埋的人非霍奇金淋巴瘤，使用的抗体是CREB (48H2) Rabbit mAb 兔单抗。 | |
Immunohistochemical analysis of paraffin-embedded human astrocytoma, using CREB (48H2) Rabbit mAb. 免疫组化分析石蜡包埋的人胶质细胞瘤，使用的抗体是CREB (48H2) Rabbit mAb 兔单抗。 | |
Immunohistochemical analysis of paraffin-embedded mouse brain, using CREB (48H2) Rabbit mAb. 免疫组化分析石蜡包埋的小鼠大脑，使用的抗体是CREB (48H2) Rabbit mAb 兔单抗。 | |
Confocal immunofluorescent analysis of SK-N-MC cells showing nuclear stain with CREB (48H2) Rabbit mAb (A, red) compared to an isotype control (B). Blue pseudocolor =DRAQ5®(fluorescent DNA dye). | |
共聚焦免疫荧光分析SK-N-MC细胞，显示出核染色，使用CREB (48H2) Rabbit mAb 兔单抗（A图，红色），与同型对照组比对（B图）。蓝色伪彩=DRAQ5® (荧光DNA染料)。 | |
Confocal immunofluorescent analysis of mouse cerebellum labeled with CREB (48H2) Rabbit mAb (red) and Neurofilament-L (DA2) Mouse mAb #2835 (green). Blue pseudocolor =DRAQ5® #4084 (fluorescent DNA dye). 共聚焦免疫荧光分析小鼠小脑，使用CREB (48H2) Rabbit mAb 兔单抗（红色）和Neurofilament-L (DA2) Mouse mAb 鼠单抗#2835（绿色）进行标记。蓝色伪彩=DRAQ5®#4084(荧光DNA染料)。 | |
