| 货号 | 29122S |
| 反应种属 | Human |
| 来源宿主 | Mouse IgG1 |
| 应用 | W/IHC-P/IF-IC |
| 使用方法 | WB(1:1000) IHC-P (1:200) |
| 供应商 | CST |
| 背景 | Programmed cell death 1 ligand 1 (PD-L1, B7-H1, CD274) is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses. The PD-L1 ligand binds the PD-1 transmembrane receptor and inhibits T cell activation. PD-L1 was discovered following a search for novel B7 protein homologs and was later shown to be expressed by antigen presenting cells, activated T cells, and tissues including placenta, heart, and lung (1-3). Similar in structure to related B7 family members, PD-L1 protein contains extracellular IgV and IgC domains and a short, cytoplasmic region. Research studies demonstrate that PD-L1 is expressed in several tumor types, including melanoma, ovary, colon, lung, breast, and renal cell carcinomas (4-6). Expression of PD-L1 in cancer is associated with tumor infiltrating lymphocytes, which mediate PD-L1 expression through the release of interferon gamma (7). Additional research links PD-L1 expression to cancers associated with viral infections (8,9). |
| 存放说明 | -20C |
| 计算分子量 | 40-50 |
Western blot analysis of extracts from various cell lines using PD-L1 (405.9A11) Mouse mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). KARPAS-299 cell line source: Dr Abraham Karpas, University of Cambridge. | |
Immunohistochemical analysis using PD-L1 (405.9A11) Mouse mAb on SignalSlide® PD-L1 IHC Controls #13747 (paraffin-embedded cell pellets, HDLM-2 (left) or PC-3 (right)). | |
Immunohistochemical analysis of parffin-embedded human tonsil using PD-L1 (405.9A11) Mouse mAb. | |
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using PD-L1 (405.9A11) Mouse mAb. | |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma using PD-L1 (405.9A11) Mouse mAb. | |
Immunohistochemical analysis of parffin-embedded human placenta using PD-L1 (405.9A11) Mouse mAb. |
