| 货号 | 15165S |
| 反应种属 | Human |
| 来源宿主 | Rabbit IgG |
| 应用 | W/IHC-P |
| 使用方法 | WB(1:1000) IHC-P (1:100) |
| 供应商 | CST |
| 背景 | Programmed cell death 1 ligand 1 (PD-L1, B7-H1, CD274) is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses. The PD-L1 ligand binds the PD-1 transmembrane receptor and inhibits T cell activation. PD-L1 was discovered following a search for novel B7 protein homologs and was later shown to be expressed by antigen presenting cells, activated T cells, and tissues including placenta, heart, and lung (1-3). Similar in structure to related B7 family members, PD-L1 protein contains extracellular IgV and IgC domains and a short, cytoplasmic region. Research studies demonstrate that PD-L1 is expressed in several tumor types, including melanoma, ovary, colon, lung, breast, and renal cell carcinomas (4-6). Expression of PD-L1 in cancer is associated with tumor infiltrating lymphocytes, which mediate PD-L1 expression through the release of interferon gamma (7). Additional research links PD-L1 expression to cancers associated with viral infections (8,9). |
| 存放说明 | -20C |
| 计算分子量 | 40-50 |
Western blot analysis of extracts from various cell lines using PD-L1 (Extracellular Domain Specific) (E1J2J) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). KARPAS cell line source: Dr. Abraham Karpas at the University of Cambridge. | |
Immunohistochemical analysis of paraffin-embedded human tonsil using PD-L1 (E1J2J) Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human colon carcinoma using PD-L1 (E1J2J) Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human placenta using PD-L1 (Extracellular Domain Specific) (E1J2J) Rabbit mAb. |
