| 货号 | 82723S |
| 反应种属 | Human |
| 来源宿主 | Rabbit IgG |
| 应用 | W/IHC-P |
| 使用方法 | WB(1:1000) IHC-P (1:200) |
| 供应商 | CST |
| 背景 | Programmed cell death 1 ligand 2 (PD-L2, B7-DC, CD273) is a member of the B7 family of cell surface ligands that regulate T-cell activation and immune responses (1,2). PD-L2 binds the PD-1 transmembrane receptor and inhibits T-cell activation. PD-L2 was discovered following a search for novel B7 protein homologs and was later shown to be expressed by activated dendritic cells, macrophages, and T-cells (1,3). Similar in structure to related B7 family members, PD-L2 protein contains extracellular IgV and IgC2 domains, a transmembrane domain, and a short, cytoplasmic region. Research studies demonstrate that PD-L2 is expressed in several tumor types, including lung cancer, renal cell carcinoma, melanoma, Hodgkins lymphoma and primary mediastinal large B-cell lymphoma (4-7). |
| 存放说明 | -20C |
| 计算分子量 | 45-60 |
Western blot analysis of HDLM-2 and Jurkat cell extracts using PD-L2 (D7U8C) XP® Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower). | |
Immunohistochemical analysis of paraffin-embedded human tonsil using PD-L2 (D7U8C) XP® Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human mediastinal large B-cell lymphoma using PD-L2 (D7U8C) XP® Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded human colon carcinoma using PD-L2 (D7U8C) XP® Rabbit mAb. | |
Immunohistochemical analysis of paraffin-embedded HDLM-2 (left) and PC-3 (right) cell pellets on SignalSlide® PD-L1 IHC Controls #13747 using PD-L2 (D7U8C) XP® Rabbit mAb. |
