Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP® Rabbit mAb (Biotinylated)
货号：
13020S 基本售价：
4460.0 元 规格：
-
产品信息
概述| 货号 | 13020S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 标记 | Biotin |
| 背景 | One way that growth factors and mitogens effectively promote sustained cell growth and proliferation is by upregulating mRNA translation (1,2). Growth factors and mitogens induce the activation of p70 S6 kinase and the subsequent phosphorylation of the S6 ribosomal protein. Phosphorylation of S6 ribosomal protein correlates with an increase in translation of mRNA transcripts that contain an oligopyrimidine tract in their 5 untranslated regions (2). These particular mRNA transcripts (5TOP) encode proteins involved in cell cycle progression, as well as ribosomal proteins and elongation factors necessary for translation (2,3). Important S6 ribosomal protein phosphorylation sites include several residues (Ser235, Ser236, Ser240, and Ser244) located within a small, carboxy-terminal region of the S6 protein (4,5). |
| 存放说明 | -20C |
| 计算分子量 | 32 |
参考图片Western blot analysis of extracts from HeLa cells, untreated (-) or treated with 20% FBS (30 min; +), using Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP® Rabbit mAb (Biotinylated). Streptavidin-HRP #3999 was used for detection. Blot分别检测untreated (-) 或经 20% FBS (30 min; +)处理的HeLa细胞提取物，使用的抗体为Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP® Rabbit mAb兔单抗 (生物素标记的)，检测二抗为Streptavidin-HRP #3999。 |
