| 货号 | 41666S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human\Mouse\Rat\Hamster\Moneky\Bovine\Pig |
| 来源宿主 | Rabbit IgG |
| 应用 | F |
| 目标/特异性 | p38 MAPK (D13E1) XP® Rabbit mAb (PE Conjugate) recognizes endogenous levels of total p38α, β, or γ MAPK protein. This antibody does not recognize p38δ, SAPK/JNK, or p44/42 MAPK proteins. |
| 使用方法 | F |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | p38 MAP kinase (MAPK), also called RK (1) or CSBP (2), is the mammalian orthologue of the yeast HOG kinase that participates in a signaling cascade controlling cellular responses to cytokines and stress (1-4). Four isoforms of p38 MAPK, p38α, β, γ (also known as Erk6 or SAPK3), and δ (also known as SAPK4) have been identified. Similar to the SAPK/JNK pathway, p38 MAPK is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharide (LPS), UV light, and growth factors (1-5). MKK3, MKK6, and SEK activate p38 MAPK by phosphorylation at Thr180 and Tyr182. Activated p38 MAPK has been shown to phosphorylate and activate MAPKAP kinase 2 (3) and to phosphorylate the transcription factors ATF-2 (5), Max (6), and MEF2 (5-8). |
| 存放说明 | 4C |
| 参考文献 | 1 . Rouse, J. et al. (1994) Cell 78, 1027-1037. 2 . Han, J. et al. (1994) Science 265, 808-11. 3 . Lee, J.C. et al. (1994) Nature 372, 739-46. 4 . Freshney, N.W. et al. (1994) Cell 78, 1039-49. 5 . Raingeaud, J. et al. (1995) J Biol Chem 270, 7420-6. 6 . Zervos, A.S. et al. (1995) Proc Natl Acad Sci U S A 92, 10531-4. 7 . Zhao, M. et al. (1999) Mol Cell Biol 19, 21-30. 8 . Yang, S.H. et al. (1999) Mol Cell Biol 19, 4028-38. 9 . Cuenda, A. et al. (1995) FEBS Lett 364, 229-33. 10 . Kumar, S. et al. (1999) Biochem Biophys Res Commun 263, 825-31. |
Flow cytometric analysis of HeLa cells using p38 MAPK (D13E1) XP® Rabbit mAb (PE Conjugate) (blue) compared to concentration-matched Rabbit (DA1E) mAb IgG XP®Isotype Control (PE Conjugate) #5742 (red). |
