| 货号 | 56831S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human\Mouse\Rat\Hamster\Moneky\Xenopus\Zebrafish\Bovine\Pig |
| 来源宿主 | Rabbit IgG |
| 应用 | F |
| 目标/特异性 | HSP60 (D6F1) XP® Rabbit mAb (PE Conjugate) recognizes endogenous levels of total HSP60 protein. |
| 使用方法 | F |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | In both prokaryotic and eukaryotic cells the misfolding and aggregation of proteins during biogenesis and under conditions of cellular stress are prevented by molecular chaperones (1-3). HSP60 has primarily been known as a mitochondrial protein that is important for folding key proteins after import into the mitochondria (4). Research studies have shown that a significant amount of HSP60 is also present in the cytosol of many cells, and that it is induced by stress, inflammatory and immune responses, and autoantibodies correlated with Alzheimers, coronary artery diseases, MS, and diabetes (5-8). |
| 存放说明 | 4C |
| 参考文献 | 1 . Hartl, F.U. (1996) Nature 381, 571-579. 2 . Bukau, B. and Horwich, A.L. (1998) Cell 92, 351-366. 3 . Hartl, F.U. and Hayer-Hartl, M. (2002) Science 295, 1852-1858. 4 . Jindal, S. et al. (1989) Mol. Cell Biol. 9, 2279-2283. 5 . Itoh, H. et al. (2002) Eur. J. Biochem. 269, 5931-5938. 6 . Gupta, S. and Knowlton, A.A. J. Cell Mol. Med. 9, 51-58. 7 . Deocaris, C.C. et al. (2006) Cell Stress Chaperones 11, 116-128. 8 . Lai, H.C. et al. (2007) Am. J. Physiol. Endocrinol. Metab. 292, E292-E297. |
Flow cytometric analysis of HeLa cells using HSP60 (D6F1) XP® Rabbit mAb (PE Conjugate) (blue) compared to concentration-matched Rabbit (DA1E) mAb IgG XP®Isotype Control (PE Conjugate) #5742 (red). |
