| 货号 | 93920S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human |
| 应用 | WB |
| 目标/特异性 | HGF β (D6S7D) XP® Rabbit mAb (Biotinylated) recognizes endogenous levels of total HGF protein. |
| 使用方法 | Western Blotting (1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | The Hepatocyte Growth Factor (HGF, also known as Scatter Factor) was initially discovered as a mitogenic cytokine that induced hepatocyte replication and proliferation (1-3). HGF is produced by stromal cells where it is processed by extracellular serine proteases into a heterodimer consisting of alpha and beta subunits (4). Through activation of its receptor, cMET, HGF has a wide range of effects beyond hepatocytes that includes angiogenesis, epithelial cell proliferation and morphogenesis, and tissue protection and regeneration (5). The HGF-cMET axis has been associated with several diseases, including cancer, where HGF has been shown to promote invasion, metastasis, and drug resistance (6,7). These research studies suggest that HGF is a potential diagnostic and therapeutic target. |
| 存放说明 | -20C |
| 计算分子量 | 35, 85 |
| 参考文献 | 1 . Nakamura, T. et al. (1984) Biochem Biophys Res Commun 122, 1450-9. 2 . Russell, W.E. et al. (1984) J Cell Physiol 119, 183-92. 3 . Gohda, E. et al. (1988) J Clin Invest 81, 414-9. 4 . Kataoka, H. et al. Cancer Metastasis Rev 22, 223-36. 5 . Nakamura, T. and Mizuno, S. (2010) Proc Jpn Acad Ser B Phys Biol Sci 86, 588-610. 6 . Matsumoto, K. and Nakamura, T. (2006) Int J Cancer 119, 477-83. 7 . Yano, S. et al. (2008) Cancer Res 68, 9479-87. |
Western blot analysis of extracts from A-204 and HeLa cells using HGF β (D6S7D) XP® Rabbit mAb (Biotinylated). |
