| 货号 | 65432S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human, Mouse |
| 应用 | F |
| 目标/特异性 | Helios (D8W4X) XP® Rabbit mAb (Alexa Fluor® 647 Conjugate) recognizes endogenous levels of total Helios protein. |
| 使用方法 | Flow Cytometry (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Helios (Ikaros family zinc finger 2, IZKF2) is an Ikaros family transcription factor composed of several zinc fingers that mediate DNA binding and homodimerization or heterodimerization with other Ikaros family proteins (1,2). In the hematopoietic system, Helios expression is restricted to T cells and early hematopoietic progenitors (1,2). In regulatory T cells, expression of Helios contributes to an anergic phenotype by binding to the IL-2 promoter and suppressing IL-2 transcription (3). In addition, alteration of the corresponding Helios gene IZKF2 is one hallmark of low-hypodiploid acute lymphoblastic leukemia (4). |
| 存放说明 | 4C |
| 参考文献 | 1 . Hahm, K. et al. (1998) Genes Dev 12, 782-96. 2 . Kelley, C.M. et al. (1998) Curr Biol 8, 508-15. 3 . Baine, I. et al. (2013) J Immunol 190, 1008-16. 4 . Holmfeldt, L. et al. (2013) Nat Genet 45, 242-52. |
Flow cytometric analysis of RL-7 cells (blue) and Jurkat cells (green) using Helios (D8W4X) XP® Rabbit mAb (Alexa Fluor® 647 Conjugate). |
