ALK (D5F3®) XP® Rabbit mAb (HRP Conjugate)
货号：
31278S 基本售价：
4264.0 元 规格：
-
产品信息
概述| 货号 | 31278S |
| 反应种属 | Human |
| 来源宿主 | Rabbit IgG |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor for pleiotrophin (PTN), a growth factor involved in embryonic brain development (1-3). In ALK-expressing cells, PTN induces phosphorylation of both ALK and the downstream effectors IRS-1, Shc, PLCγ, and PI3 kinase (1). ALK was originally discovered as a nucleophosmin (NPM)-ALK fusion protein produced by a translocation (4). Investigators have found that the NPM-ALK fusion protein is a constitutively active, oncogenic tyrosine kinase associated with anaplastic lymphoma (4). Research literature suggests that activation of PLCγ by NPM-ALK may be a crucial step for its mitogenic activity and involved in the pathogenesis of anaplastic lymphomas (5). |
| 存放说明 | -20C |
| 计算分子量 | 220 (ALK), 80 (NPM-ALK), 117 (EML4-ALK v1), 86 (EML4-ALK v3) |
参考图片Western blot analysis of extracts from NCI-H2228 and NCI-H3122 cells using ALK (D5F3®) XP® Rabbit mAb (HRP Conjugate). Variants denoting fusions of different EML4 exons (v1 or v3) are indicated. |
