Caveolin-1 (D46G3) XP® Rabbit mAb (HRP Conjugate)
货号：
12506S 基本售价：
4264.0 元 规格：
-
产品信息
概述| 货号 | 12506S |
| 描述 | This Cell Signaling Technology® antibody is conjugated to the carbohydrate groups of horseradish peroxidase (HRP) via its amine groups. The HRP conjugated antibody is expected to exhibit the same species cross-reactivity as the unconjugated Caveolin-1 (D46G3) XP® Rabbit mAb #3267. |
| 反应种属 | Human/Mouse/Rat/Hamster/Monkey/Bovine/Dog |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Caveolin-1 (D46G3) XP® Rabbit mAb (HRP Conjugate) detects endogenous levels of total caveolin-1 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 标记 | HRP |
| 背景 | The 21-24 kDa integral proteins, caveolins, are the principal structural components of the cholesterol/sphingolipid-enriched plasma membrane microdomain caveolae. Three members of the caveolin family (caveolin-1, -2, and -3) have been identified with different tissue distributions. Caveolins form hetero- and homo-oligomers that interact with cholesterol and other lipids (1). Caveolins are involved in diverse biological functions, including vesicular trafficking, cholesterol homeostasis, cell adhesion, and apoptosis, and are also implicated in neurodegenerative disease (2). Caveolins interact with multiple signaling molecules such as Gα subunit, tyrosine kinase receptors, PKCs, Src family tyrosine kinases, and eNOS (1,2). It is believed that caveolins serve as scaffolding proteins for the integration of signal transduction. Phosphorylation at Tyr14 is essential for caveolin association with SH2 or PTB domain-containing adaptor proteins such as GRB7 (3-5). Phosphorylation at Ser80 regulates caveolin binding to the ER membrane and entry into the secretory pathway (6). |
| 存放说明 | -20C |
| 计算分子量 | 21, 24 |
参考图片Western blot analysis of extracts from HeLa and NIH/3T3 cells using Caveolin-1 (D46G3) XP® Rabbit mAb (HRP Conjugate). Western blot方法检测 HeLa 和NIH/3T3细胞的提取物，使用的抗体为Caveolin-1 (D46G3) XP® Rabbit mAb (HRP 接合)。 |
