Ezh2 (D2C9) XP® Rabbit mAb (Biotinylated)
货号：
12408S 基本售价：
4264.0 元 规格：
-
产品信息
概述| 货号 | 12408S |
| 描述 | This Cell Signaling Technology antibody is conjugated to biotin under optimal conditions. The biotinylated antibody is expected to exhibit the same species cross-reactivity as the unconjugated Ezh2 (D2C9) XP® Rabbit mAb #5246. |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Ezh2 (D2C9) XP® Rabbit mAb (Biotinylated) recognizes endogenous levels of total Ezh2 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 标记 | Biotin |
| 背景 | The polycomb group (PcG) proteins are involved in maintaining the silenced state of several developmentally regulated genes and contribute to the maintenance of cell identity, cell cycle regulation, and oncogenesis (1,2). Enhancer of zeste homolog 2 (Ezh2), a member of this large protein family, contains four conserved regions including domain I, domain II, and a cysteine-rich amino acid stretch that precedes the carboxy-terminal SET domain (3). The SET domain has been linked with histone methyltransferase (HMTase) activity. Moreover, mammalian Ezh2 is a member of a histone deacetylase complex that functions in gene silencing, acting at the level of chromatin structure (4). Ezh2 complexes methylate histone H3 at Lys9 and 27 in vitro, which is thought to be involved in targeting transcriptional regulators to specific loci (5). Ezh2 is deregulated in various tumor types, and its role, both as a primary effector and as a mediator of tumorigenesis, has become a subject of increased interest (6). |
| 存放说明 | -20C |
| 计算分子量 | 98 |
参考图片Western blot analysis of extracts from MCF7 and COS-7 cells using Ezh2 (D2C9) XP® Rabbit mAb (Biotinylated). Streptavidin-HRP #3999 was used for western detection.Western blot方法检测MCF7和COS-7 细胞的提取物，使用的抗体为Ezh2 (D2C9) XP® Rabbit mAb (Biotinylated) 。Streptavidin-HRP #3999被用于Western检测。 |
