FGF Receptor 1 (D8E4) XP® Rabbit mAb (Biotinylated)
货号：
12511S 基本售价：
4264.0 元 规格：
-
产品信息
概述| 货号 | 12511S |
| 描述 | This Cell Signaling Technology antibody is conjugated to biotin under optimal conditions. The biotinylated antibody is expected to exhibit the same species cross-reactivity as the unconjugated FGF Receptor 1 (D8E4) XP® Rabbit mAb #9740. |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | FGF Receptor 1 (D8E4) XP® Rabbit mAb (Biotinylated) recognizes endogenous levels of total FGF receptor 1 protein. This antibody does not cross-react with other FGF receptor family members. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 标记 | Biotin |
| 背景 | Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through cell surface receptor tyrosine kinases. There are four members of the FGF receptor family: FGFR1 (flg), FGFR2 (bek, KGFR), FGFR3, and FGFR4. Each receptor contains an extracellular ligand binding domain, a transmembrane domain, and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR1 can be phosphorylated: Tyr463, 583, 585, 653, 654, 730, and 766. Tyr653 and Tyr654 are important for catalytic activity of activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCγ (4,5). |
| 存放说明 | -20C |
| 计算分子量 | 92, 120, 145 |
参考图片Western blot analysis of extracts from A-204 cells using FGF Receptor 1 (D8E4) XP® Rabbit mAb (Biotinylated). Streptavidin-HRP #3999 was used for western detection.Western blot方法检测A-204细胞提取物，使用的抗体为FGF Receptor 1 (D8E4) XP® Rabbit mAb (Biotinylated)。Western检测使用Streptavidin-HRP #3999。 |
