Mer (D21F11) XP® Rabbit mAb (Sepharose®Bead Conjugate)
货号：
3551S 基本售价：
4264.0 元 规格：
-
产品信息
概述| 货号 | 3551S |
| 描述 | This Cell Signaling Technology antibody is immobilized via covalent binding of primary amino groups to N-hydroxysuccinimide (NHS)-activated sepharose beads. Mer (D21F11) XP® Rabbit mAb (Sepharose Bead Conjugate) is useful for the immunoprecipitation of Mer. The antibody is expected to exhibit the same species cross-reactivity as the unconjugated Mer (D21F11) XP® Rabbit mAb #4319. |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | IP |
| 目标/特异性 | Mer (D21F11) XP® Rabbit mAb (Sepharose Bead Conjugate) detects endogenous levels of total Mer protein. |
| 使用方法 | IP(1:20) |
性能| 供应商 | CST |
| 标记 | Sepharose Bead |
| 背景 | Mer tyrosine kinase belongs to a receptor tyrosine kinase family with Axl and Tyro3. This family is characterized by a common NCAM (neural adhesion molecule)-related extracellular domain and a common ligand, GAS6 (growth arrest-specific protein 6). Mer protein has an apparent molecular weight of 170-210 kDa due to different glycosylation patterns generated in different cell types. Mer can be activated by dimerization and autophosphorylation through ligand binding or homophilic cell-cell interaction mediated by its NCAM-like motif (1). The downstream signaling components of activated Mer include PI3 kinase, PLCγ, and MAP kinase (2). Family members are prone to transcriptional regulation and carry out diverse functions including the regulation of cell adhesion, migration, phagocytosis, and survival (3). Mer regulates macrophage activation, promotes apoptotic cell engulfment, and supports platelet aggregation and clot stability in vivo (4). Investigators ahve found that overexpression of Mer may play a cooperative role in leukemogenesis and may be an effective target for biologically based leukemia/lymphoma therapy (5). |
| 存放说明 | -20C |
| 计算分子量 | 210 |
参考图片Immunoprecipitation of Jurkat and Hep G2 cell lysates using Mer (D21F11) XP® Rabbit mAb (Sepharose Bead Conjugate) and Rabbit (DA1E) mAb IgG XP® Isotype Control (Sepharose Bead Conjugate) #3423. The western blot was probed using Mer (D21F11) XP® Rabbit mAb #4319.免疫沉淀方法检测Jurkat细胞和Hep G2细胞裂解物，使用的抗体为Mer (D21F11) XP® Rabbit mAb (琼脂糖珠结合)和Rabbit (DA1E) mAb IgG XP® Isotype Control (琼脂糖珠结合) #3423. 探索的western blot使用的抗体为Mer (D21F11) XP® Rabbit mAb #4319. |
Immunoprecipitation of Hep G2 cell lysates using Mer (D21F11) XP® Rabbit mAb (Sepharose Bead Conjugate) and Rabbit (DA1E) mAb IgG XP® Isotype Control (Sepharose Bead Conjugate) #3423. The western blot was probed using Mer (348E6) Mouse mAb #9178.免疫沉淀方法检测Hep G2细胞裂解物，使用的抗体为Mer (D21F11) XP® Rabbit mAb (琼脂糖珠结合)和Rabbit (DA1E) mAb IgG XP® Isotype Control (琼脂糖珠结合) #3423. 探索的western blot使用的抗体为Mer (348E6) Mouse mAb #9178. |
