Smad2 (D43B4) XP® Rabbit mAb (Biotinylated)
货号：
12584S 基本售价：
4264.0 元 规格：
-
产品信息
概述| 货号 | 12584S |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 标记 | Biotin |
| 背景 | Members of the Smad family of signal transduction molecules are components of a critical intracellular pathway that transmit TGF-β signals from the cell surface into the nucleus. Three distinct classes of Smads have been defined: the receptor-regulated Smads (R-Smads), which include Smad1, 2, 3, 5, and 8; the common-mediator Smad (co-Smad), Smad4; and the antagonistic or inhibitory Smads (I-Smads), Smad6 and 7 (1-5). Activated type I receptors associate with specific R-Smads and phosphorylate them on a conserved carboxy terminal SSXS motif. The phosphorylated R-Smad dissociates from the receptor and forms a heteromeric complex with the co-Smad (Smad4), allowing translocation of the complex to the nucleus. Once in the nucleus, Smads can target a variety of DNA binding proteins to regulate transcriptional responses (6-8). |
| 存放说明 | -20C |
| 计算分子量 | 60 |
参考图片Western blot analysis of extracts from HeLa and C2C12 cells using Smad2 (D43B4) XP®Rabbit mAb (Biotinylated). 使用 Smad2 (D43B4) XP®Rabbit mAb (生物素标记)对HeLa 和C2C12细胞进行Western blot分析。 |
