| 货号 | 83667S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | H M R Hm Mk |
| 来源宿主 | Rabbit IgG |
| 应用 | W |
| 目标/特异性 | Mitofusin-2 (D2D10) Rabbit mAb (HRP Conjugate) recognizes endogenous levels of total mitofusin-2 protein. |
| 使用方法 | WB(1:1000) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Mitofusins are mitochondrial transmembrane GTPases that function to regulate mitochondrial fusion, a process that occurs in concert with mitochondrial division and is necessary for the maintenance of structural and genetic mitochondrial integrity (1,2). Two mitofusins have been described in mammals, mitofusin-1 and -2, which share 60% amino acid identity and appear to function coordinately to regulate mitochondrial fusion (3). Mitochondrial fusion is widely recognized as important for normal cell growth and development (4), and may have evolved as a mechanism to offset the deleterious effects of mtDNA mutations (3). Null mutations in either mitofusin are embryonic lethal in mice, whereas conditional knockout studies have shown that combined deletion of mitofusin-1 and mitofusin-2 in skeletal muscle results in severe mitochondrial dysfunction (3). |
| 运输条件 | 0.75 |
| 存放说明 | -20C |
| 计算分子量 | 80 |
| 参考文献 | 1 . Zhang, Y. and Chan, D.C. (2007) FEBS Lett 581, 2168-73. 2 . Chan, D.C. (2006) Annu Rev Cell Dev Biol 22, 79-99. 3 . Chen, H. et al. (2010) Cell 141, 280-9. 4 . Bereiter-Hahn, J. and Vöth, M. (1994) Microsc Res Tech 27, 198-219. |
Western blot analysis of extracts from PC3 and C6 cells using Mitofusin-2 (D2D10) Rabbit mAb (HRP Conjugate). |
