| 货号 | 25357S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | H M R |
| 来源宿主 | Rabbit IgG |
| 应用 | F |
| 目标/特异性 | EGR1 (44D5) Rabbit mAb (PE Conjugate) detects endogenous levels of total EGR1 protein. |
| 使用方法 | F(1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | EGR family members are transcriptional factors that contain three repetitive zinc finger DNA binding domains which bind to EGR response elements (ER) to regulate target gene expression (1). The expression of EGR family members is induced by growth factors, with EGR1 expression being induced by NGF (1,2). Increased EGR1 expression activates transcription of other signaling molecules, including CDK5 and tyrosine hydroxylase, and exerts long term effects on neural cell growth and differentiation (2,3). |
| 运输条件 | 0.75 |
| 存放说明 | 4C |
| 参考文献 | 1 . ODonovan, K.J. et al. (1999) Trends Neurosci. 22, 167-173. 2 . Harada, T. et al. (2001) Nat. Cell Biol. 3, 453-459. 3 . Papanikolaou, N.A. and Sabban, E.L. (2000) J. Biol. Chem. 275, 26683-26689. |
Flow cytometric analysis of Jurkat cells, untreated (blue) or treated with TPA #4174 (200 nM, 2 hours) and Ionomycin, Calcium Salt #9995 (3 µM, 2 hours) (green), using EGR1 (44D5) Rabbit mAb (PE Conjugate). |
