| 货号 | 12099S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human, Mouse, Rat, Monkey |
| 应用 | F |
| 目标/特异性 | Bcl-xL (54H6) Rabbit mAb (APC Conjugate) detects endogenous levels of total Bcl-xL protein. The antibody does not cross-react with other Bcl-2 family members. |
| 使用方法 | Flow Cytometry (1:50) |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Bcl-xL prevents apoptosis through two different mechanisms: heterodimerization with an apoptotic protein inhibits its apoptotic effect (1,2) and formation of mitochondrial outer membrane pores help maintain a normal membrane state under stressful conditions (3). Bcl-xL is phosphorylated by JNK following treatment with microtubule-damaging agents such as paclitaxel, vinblastine and nocodazole (4,5). |
| 存放说明 | -20C |
| 参考文献 | 1 . Adams, J.M. and Cory, S. (1998) Science 281, 1322-6. 2 . Minn, A.J. et al. (1999) EMBO J 18, 632-43. 3 . Vander Heiden, M.G. et al. (2001) J Biol Chem 276, 19414-9. 4 . Fan, M. et al. (2000) J Biol Chem 275, 29980-5. 5 . Poruchynsky, M.S. et al. (1998) Cancer Res 58, 3331-8. |
Flow cytometric analysis of SEM cells (blue) or K-562 cells (green) using Bcl-xL (54H6) Rabbit mAb (APC Conjugate). |
