| 货号 | 54516S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human\Mouse |
| 来源宿主 | Rabbit IgG |
| 应用 | F |
| 目标/特异性 | NBR1 (D2E6) Rabbit mAb (PE Conjugate) recognizes endogenous levels of total NBR1 protein. |
| 使用方法 | F |
| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Next to BRCA1 gene 1 (NBR1) protein is known for its encoding gene proximity to the BRCA1 tumor suppressor gene (1,2). N-terminal Phox and Bem1p (PB1) domains of NBR1 mediate its interaction with muscle specific titin kinase (3,4) and scaffolding protein p62 (4). NBR1 plays a role in autophagy by facilitating the autophagosomal degradation of ubiquitinated proteins independently and also in concert with p62 (5,6). |
| 存放说明 | 4C |
| 参考文献 | 1 . Campbell, I.G. et al. (1994) Hum Mol Genet 3, 589-94. 2 . Miki, Y. et al. (1994) Science 266, 66-71. 3 . Lange, S. et al. (2005) Science 308, 1599-603. 4 . Müller, S. et al. (2006) FEBS Lett 580, 341-4. 5 . Kirkin, V. et al. (2009) Mol Cell 33, 505-16. 6 . Lamark, T. et al. (2009) Cell Cycle 8, 1986-90. |
Flow cytometric analysis of HeLa cells using NBR1 (D2E6) Rabbit mAb (PE Conjugate) (blue) compared to concentration-matched Rabbit (DA1E) mAb IgG XP® Isotype Control (PE Conjugate) #5742 (red). |
