β-Catenin (L54E2) Mouse mAb (Alexa Fluor® 555 Conjugate)
货号：
5612S 基本售价：
4060.0 元 规格：
-
产品信息
概述| 货号 | 5612S |
| 描述 | This Cell Signaling Technology antibody is conjugated to Alexa Fluor® 555 fluorescent dye and tested in-house for immunofluorescence in human cells. The antibody is expected to exhibit the same species cross-reactivity as the unconjugated β-Catenin (L54E2) Mouse mAb (IF Preferred) #2677. |
| 反应种属 | Human |
| 来源宿主 | Mouse |
| 应用 | IF-IC |
| 使用方法 | IF-IC(1:50) |
性能| 供应商 | CST |
| 标记 | Alexa Fluor 555 |
| 背景 | β-Catenin is a key downstream effector in the Wnt signaling pathway (1). It is implicated in two major biological processes in vertebrates: early embryonic development (2) and tumorigenesis (3). CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β (4-6). GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41 (7). Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines (8). |
| 存放说明 | 4C |
参考图片Confocal immunofluorescent analysis of HeLa (left) and NCI-H28 (right) cells using β-Catenin (L54E2) Mouse mAb (Alexa Fluor® 555 Conjugate) (red) and a Histone H3 Antibody (green). 用 β-Catenin (L54E2)鼠单抗（Alexa Fluor® 555 偶联）（红色）和Histone H3 抗体（绿色）对HeLa（左）和NCI-H28细胞（右）进行激光共聚焦荧光分析。 |
