β-Amyloid (1-37 Specific) (D2A6H) Rabbit mAb (Biotinylated)
货号：
12356S 基本售价：
4060.0 元 规格：
-
产品信息
概述| 货号 | 12356S |
| 描述 | This Cell Signaling Technology antibody is conjugated to biotin under optimal conditions. The biotinylated antibody is expected to exhibit the same species cross-reactivity as the unconjugated β-Amyloid (1-37 Specific) (D2A6H) Rabbit mAb #12467. |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | β-Amyloid (1-37 Specific) (D2A6H) Rabbit mAb (Biotinylated) recognizes the Aβ-37 isoform of the β-amyloid peptides. This antibody does not cross-react with other β-amyloid peptides. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 标记 | Biotin |
| 背景 | Amyloid β (Aβ) precursor protein (APP) is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms (1). The amino acid sequence of APP contains the amyloid domain, which can be released by a two-step proteolytic cleavage (1). The extracellular deposition and accumulation of the released Aβ fragments form the main components of amyloid plaques in Alzheimers disease (1). APP can be phosphorylated at several sites, which may affect the proteolytic processing and secretion of this protein (2-5). Phosphorylation at Thr668 (a position corresponding to the APP695 isoform) by cyclin-dependent kinase is cell-cycle dependent and peaks during G2/M phase (4). APP phosphorylated at Thr668 exists in adult rat brain and correlates with cultured neuronal differentiation (5,6). |
| 存放说明 | -20C |
| 计算分子量 | 4 |
参考图片Western blot analysis of human Aβ-37, Aβ-40 and Aβ-42 peptides using β-Amyloid (1-37 Specific) (D2A6H) Rabbit mAb (Biotinylated). Streptavidin-HRP #3999 was used for western detection. Western blot检测人Aβ-37，Aβ-40和 Aβ-42 肽段，使用的抗体为β-Amyloid (1-37 Specific) (D2A6H) Rabbit mAb (Biotinylated)兔单抗。Streptavidin-HRP #3999 被用于 western检测。 |
