Caspase-3 (8G10) Rabbit mAb (HRP Conjugate)
货号：
29629S 基本售价：
4060.0 元 规格：
-
产品信息
概述| 货号 | 29629S |
| 同种亚型 | Rabbit IgG |
| 反应种属 | Human, Mouse, Rat, Monkey |
| 应用 | WB |
| 目标/特异性 | Caspase-3 (8G10) Rabbit mAb (HRP Conjugate) detects endogenous levels of full-length (35 kDa) caspase-3 as well as its 17 and 19 kDa fragments resulting from cleavage at aspartic acid 175. |
| 使用方法 | Western Blotting (1:1000)
|
性能| 供应商 | CST |
| 灵敏度 | Endogenous |
| 背景 | Caspase-3 (CPP-32, Apoptain, Yama, SCA-1) is a critical executioner of apoptosis, as it is either partially or totally responsible for the proteolytic cleavage of many key proteins, such as the nuclear enzyme poly (ADP-ribose) polymerase (PARP) (1). Activation of caspase-3 requires proteolytic processing of its inactive zymogen into activated p17 and p12 fragments. Cleavage of caspase-3 requires the aspartic acid residue at the P1 position (2). |
| 存放说明 | -20C |
| 计算分子量 | 17,19,35 |
| 参考文献 | 1 . Fernandes-Alnemri, T. et al. (1994) J Biol Chem 269, 30761-4.
2 . Nicholson, D. W. et al. (1995) Nature 376, 37-43.
|
参考图片Western blot analysis of HeLa cell extracts, untreated (-) or treated with staurosporine (1 μM, 3 hr; +), using Caspase-3 (8G10) Rabbit mAb (HRP Conjugate). |
