CREB (48H2) Rabbit mAb (Biotinylated)
货号：
4034S 基本售价：
4060.0 元 规格：
-
产品信息
概述| 货号 | 4034S |
| 描述 | This Cell Signaling Technology antibody is conjugated to biotin under optimal conditions. The biotinylated antibody is expected to exhibit the same species cross reactivity as the unconjugated CREB (48H2) Rabbit mAb #9197. |
| 反应种属 | Human/Mouse/Rat/Monkey/D.melanogaster |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | CREB (48H2) Rabbit mAb (Biotinylated) detects endogenous levels of total CREB protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 标记 | Biotin |
| 背景 | CREB is a bZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth, and neuronal differentiation in certain neuronal populations (1-3). Additionally, CREB signaling is involved in learning and memory in several organisms (4-6). CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+, and stress signaling. Some of the kinases involved in phosphorylating CREB at Ser133 are p90RSK, MSK, CaMKIV, and MAPKAPK-2 (7-9). |
| 存放说明 | -20C |
| 计算分子量 | 43 |
参考图片Western blot analysis of extracts from NIH/3T3 and SK-N-MC cells using CREB (48H2) Rabbit mAb (Biotinylated) and developed using Streptavidin-HRP #3999. Western blot分析NIH/3T3和SK-N-MC细胞提取物，使用的抗体是CREB (48H2) Rabbit mAb (Biotinylated)，然后使用Streptavidin-HRP #3999。 |
