IRAK1 (D51G7) Rabbit mAb (Biotinylated)
货号：
11123S 基本售价：
4060.0 元 规格：
-
产品信息
概述| 货号 | 11123S |
| 描述 | This Cell Signaling Technology antibody is conjugated to biotin under optimal conditions. The biotinylated antibody is expected to exhibit the same species cross-reactivity as the unconjugated IRAK1 (D51G7) XP® Rabbit mAb #4504. |
| 反应种属 | Human/Mouse/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | IRAK1 (D51G7) XP® Rabbit mAb (Biotinylated) detects endogenous levels of total IRAK1 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 标记 | Biotin |
| 背景 | Interleukin-1 (IL-1) receptor-associated kinase (IRAK) is a serine/threonine-specific kinase that can be coprecipitated in an IL-1-inducible manner with the IL-1 receptor (1). The mammalian family of IRAK molecules contains four members (IRAK1, IRAK2, IRAK3/IRAK-M, and IRAK4). The binding of IL-1 to IL-1 receptor type I (IL-1RI) initiates the formation of a complex that includes IL-1RI, AcP, MyD88, and IRAKs (2). IRAK undergoes autophosphorylation shortly after IL-1 stimulation. The subsequent events involve IRAK dissociation from the IL-1RI complex, its ubiquitination, and its association with two membrane-bound proteins: TAB2 and TRAF6. The resulting IRAK-TRAF6-TAB2 complex is then released into the cytoplasm where it activates protein kinase cascades, including TAK1, IKKs, and the stress-activated kinases (3). |
| 存放说明 | -20C |
| 计算分子量 | 78-105 |
参考图片Western blot analysis of extracts from various cell lines using IRAK1 (D51G7) XP® Rabbit mAb (Biotinylated). Streptavidin-HRP #3999 was used for detection.Western免疫印迹。用IRAK1 (D51G7) XP® Rabbit mAb (Biotinylated)研究各种细胞系的细胞提取液。Streptavidin-HRP #3999 用于检测。 |
