ROS1 (D4D6®) Rabbit mAb (Biotinylated)
货号：
12368S 基本售价：
4060.0 元 规格：
-
产品信息
概述| 货号 | 12368S |
| 描述 | This Cell Signaling Technology antibody is conjugated to biotin under optimal conditions. The biotinylated antibody is expected to exhibit the same species cross-reactivity as the unconjugated ROS1 (D4D6) Rabbit mAb #3287. |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | ROS1 (D4D6) Rabbit mAb (Biotinylated) recognizes endogenous levels of total ROS1 protein. This antibody does not cross-react with other related proteins when analyzed by western blot. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 标记 | Biotin |
| 背景 | ROS1, an orphan receptor tyrosine kinase of the insulin receptor family, was initially identified as a homolog of v-ros from the UR2 sarcoma virus (1). ROS1 consists of a large extracellular domain that is composed of six fibronectin repeats, a transmembrane domain, and an intracellular kinase domain. While the function of ROS1 is undefined, it has been shown to play an important role in differentiation of epididymal epithelium (2). The first oncogenic fusion of ROS1, FIG-ROS1, was initially identified by research studies in glioblastoma (3), and subsequent studies have found this fusion in cholangiocarcinoma (4), ovarian cancer (5) and non-small cell lung cancer (NSCLC) (6). Investigators have found additional oncogenic ROS1 fusion proteins in NSCLC (at a frequency of ~1.6%), where the ROS1 kinase domain is fused to the amino-terminal region of a number of different proteins, including CD74 and SLC34A2 (6-8). ROS1 fusion proteins activate the SHP-2 phosphatase, PI3K/Akt/mTOR, Erk, and Stat3 pathways (3,4,9). |
| 存放说明 | -20C |
| 计算分子量 | 258, 110, 50-80 |
参考图片Western blot analysis of extracts from HCC78 cells using ROS1 (D4D6) Rabbit mAb (Biotinylated). Streptavidin-HRP #3999 was used for western detection.Western blot方法检测HCC78细胞的提取物，使用的抗体为ROS1 (D4D6) Rabbit mAb (Biotinylated)。用Streptavidin-HRP #3999进行western检测。 |
