Stat3 (79D7) Rabbit mAb (Biotinylated)
货号：
8232S 基本售价：
4060.0 元 规格：
-
产品信息
概述| 货号 | 8232S |
| 描述 | This Cell Signaling Technology antibody is conjugated to biotin under optimal conditions. The biotinylated antibody is expected to exhibit the same species cross-reactivity as the unconjugated Stat3 (79D7) Rabbit mAb #4904. |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Stat3 (79D7) Rabbit mAb (Biotinylated) recognizes endogenous levels of total Stat3 protein. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 标记 | Biotin |
| 背景 | The Stat3 transcription factor is an important signaling molecule for many cytokines and growth factor receptors (1) and is required for murine fetal development (2). Stat3 is constitutively activated in a number of human tumors (3,4) and possesses oncogenic potential (5) and anti-apoptotic activities (3). Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation, and DNA binding (6,7). Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways (8,9). Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3α (86 kDa) and Stat3β (79 kDa) depend on cell type, ligand exposure, or cell maturation stage (10). It is notable that Stat3β lacks the serine phosphorylation site within the carboxy-terminal transcriptional activation domain (8). |
| 存放说明 | -20C |
| 计算分子量 | 79, 86 |
参考图片Western blot analysis of extracts from NIH/3T3 and HeLa cells using Stat3 (79D7) Rabbit mAb (Biotinylated). Streptavidin-HRP #3999 was used for western detection.Western blot分析 NIH/3T3 和HeLa细胞的细胞提取物，使用抗体是 Stat3 (79D7) Rabbit mAb (Biotinylated).。 Streptavidin-HRP #3999用作Western blot检测。 |
