Stat3 (79D7) Rabbit mAb (Sepharose® Bead Conjugate)
货号：
4368S 基本售价：
4060.0 元 规格：
-
产品信息
概述| 货号 | 4368S |
| 描述 | This Cell Signaling Technology antibody is immobilized via covalent binding of primary amino groups to N-hydroxysuccinimide (NHS)-activated sepharose beads. Stat3 (79D7) Rabbit mAb (Sepharose Bead Conjugate) is useful for the immunoprecipitation assay of Stat3 proteins. |
| 反应种属 | Human/Mouse/Rat/Monkey |
| 来源宿主 | Rabbit |
| 应用 | IP |
| 目标/特异性 | Stat3 (79D7) Rabbit mAb (Sepharose Bead Conjugate) detects endogenous levels of total Stat3 protein. |
| 使用方法 | IP(1:20) |
性能| 供应商 | CST |
| 标记 | Sepharose Bead |
| 背景 | The Stat3 transcription factor is an important signaling molecule for many cytokines and growth factor receptors (1) and is required for murine fetal development (2). Stat3 is constitutively activated in a number of human tumors (3,4) and possesses oncogenic potential (5) and anti-apoptotic activities (3). Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation, and DNA binding (6,7). Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways (8,9). Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3α (86 kDa) and Stat3β (79 kDa) depend on cell type, ligand exposure, or cell maturation stage (10). It is notable that Stat3β lacks the serine phosphorylation site within the carboxy-terminal transcriptional activation domain (8). |
| 存放说明 | -20C |
| 计算分子量 | 79, 86 |
参考图片Immunoprecipitation of NIH/3T3 cell lysates using Rabbit (DA1E) mAb IgG XP® Isotype Control (Sepharose Bead Conjugate) #3423 and Stat3 (79D7) Rabbit mAb (Sepharose Bead Conjugate). The western blot was probed using Stat3 (124H6) Mouse mAb #9139.免疫共沉淀NIH/3T3 细胞裂解液。所用抗体为Rabbit (DA1E) mAb IgG XP® Isotype Control (Sepharose Bead Conjugate) #3423和Stat3 (79D7) Rabbit mAb (Sepharose Bead Conjugate)。western免疫印迹以Stat3 (124H6) Mouse mAb #9139为探针。 |
