Cleaved Caspase-8 (Asp384) (11G10) Mouse mAb
货号：
9748S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 9748S |
| 反应种属 | Human |
| 来源宿主 | Mouse |
| 应用 | W |
| 目标/特异性 | Cleaved Caspase-8 (Asp384) (11G10) Mouse mAb detects endogenous levels of the small fragment of caspase-8 resulting from cleavage at aspartic acid 384. The antibody does not cross-react with full length caspase-8. |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10 (1-3). Activated caspase-8 cleaves and activates downstream effector caspases such as caspase-1, -3, -6, and -7. Caspase-3 ultimately elicits the morphological hallmarks of apoptosis, including DNA fragmentation and cell shrinkage. |
| 存放说明 | -20C |
| 计算分子量 | 10 |
参考图片Western blot analysis of extracts from SKW6.4 cells, untreated or anti-Fas-treated (1 µg/ml), using Cleaved Caspase-8 (Asp384) (11G10) Mouse mAb (left) or Caspase-8 (1C12) Mouse mAb #9746 (right). 采用抗体 Cleaved Caspase-8 (Asp384) (11G10) Mouse mAb 鼠单抗(左) or Caspase-8 (1C12) Mouse mAb 鼠单抗#9746 (右)对未处理或抗Fas抗体 (1 µg/ml)处理的SKW6.4 细胞进行Western blot 分析 |
