| 货号 | 5617S |
| 反应种属 | Human/Mouse/Monkey |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 使用方法 | WB(1:1000) IP (1:100) |
| 供应商 | CST |
| 背景 | ARHGAP family members activate Rho GTPase proteins (1). Mutations of ARHGAP family genes lead to carcinogenesis through the dysregulation of Rho/Rac/Cdc42-like GTPases (2). Little is known about the biological function of ARHGAP42, a member of the ARHGAP family. ARHGAP42 contains a RhoGAP domain in the middle of its sequence, an SH3 binding domain at the C-terminal end of the protein sequence, as well as a BAR domain and a PH domain in the N-terminal region of the sequence, which indicate that the protein may function as GTPase activator and cytoskeletal adaptor.ARHGAP家族成员激活Rho GTPase蛋白质(1)。ARHGAP家族基因的突变通过Rho/Rac/Cdc42-like GTPases异常调节导致致癌(2)。很少了解关于ARHGAP42蛋白的生理功能，其是ARHGAP家族成员之一。ARHGAP42蛋白包含一个蛋白序列中间的RhoGAP功能域、蛋白序列羧基末端SH3结合域、BAR结构域和序列氨基端PH功能域，这些表明该蛋白可能作为GTPase 激活因子和细胞骨架调节因子。 |
| 存放说明 | -20C |
| 计算分子量 | 125 |
Western blot analysis of extracts from COS-7 cells using Phospho-ARHGAP42 (Tyr376) (D45E9) Rabbit mAb. The phospho-specificity of the antibody was verified by preincubating the antibody with no peptide, phosphopeptide, or the corresponding non-phosphopeptide prior to incubating the membrane.使用Phospho-ARHGAP42 (Tyr376) (D45E9) Rabbit mAb，免疫印迹（Western Blot）分析COS-7细胞系Phospho-ARHGAP42 (Tyr376)蛋白水平。该抗体的磷酸化特异性在孵化膜之前通过预先孵育no peptide、phosphopeptide或相应的non-phosphopeptide确定。 | |
Western blot analysis of extracts from various cell lines using Phospho-ARHGAP42 (Tyr376) (D45E9) Rabbit mAb.使用Phospho-ARHGAP42 (Tyr376) (D45E9) Rabbit mAb，免疫印迹（Western Blot）分析不同细胞系Phospho-ARHGAP42 (Tyr376)蛋白水平。 |
