Phospho-Axl (Tyr702) (D12B2) Rabbit mAb
货号：
5724S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 5724S |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | Axl, Sky and Mer are three members of a receptor tyrosine kinase (RTK) family that share a conserved intracellular tyrosine kinase domain and an extracellular domain similar to those seen in cell adhesion molecules. These RTKs bind the vitamin K-dependent protein growth-arrest-specific 6 (Gas6), which is structurally related to the protein S anticoagulation factor (1). Upon binding to its receptor, Gas6 activates phosphatidylinositol 3-kinase (PI3K) and its downstream targets Akt and S6K, as well as NF-κB (2,3). A large body of evidence supports a role for Gas6/Axl signaling in cell growth and survival in normal and cancer cells (4). |
| 存放说明 | -20C |
| 计算分子量 | 138 |
参考图片Western blot analysis of extracts from NCI-H1299 cells, untreated or Gas6-treated (100 ng/ml for 10 minutes), using Phospho-Axl (Tyr702) (D12B2) Rabbit mAb (upper) or Axl (C44G1) Rabbit mAb #4566 (lower).用抗磷酸化的Axl (Tyr702)的兔源单克隆抗体（上）或抗Axl (C44G1) 的兔源单克隆抗体（下）对经过或未经Gas6 (100 ng/ml ， 10分钟)处理的NCI-H1299细胞的提取物进行免疫印迹检测。 |
