Phospho-CDC37 (Ser13) (D8P8F) Rabbit mAb
货号：
13248S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 13248S |
| 反应种属 | Human/Mouse/Rat |
| 来源宿主 | Rabbit |
| 应用 | W |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | <p>CDC37 is an important component of the HSP90 chaperone complex (1,2). It was initially identified for its involvement in cell-cycle progression and was later found to have a much broader role as a chaperone for a wide variety of kinases and other proteins (1-3). CDC37 protein has an amino-terminal kinase binding domain followed by a central HSP90 binding domain. It recruits and stabilizes kinases in the HSP90 complex by protecting the newly synthesized kinase peptide chain from degradation and promoting the next step of protein maturation (4,5). CDC37 also suppresses the ATPase activity of HSP90, thereby leading to conformational changes in the complex that preclude target kinase loading (6). CDC37 has been proposed as a therapeutic target because of its important role in multiple kinase pathways involved in proliferation and cancer cell survival, including Raf, Akt, Src, and ErbB2 pathways (7,8).</p> CDC37是HSP90分子伴侣复合物的一个重要组分（1,2）。最初它被认为参与了细胞周期进程，随后发现它具有更广泛的作用，可以作为多种激酶和蛋白的分子伴侣（1-3）。CDC37蛋白由一个氨基端激酶结合结构域，紧跟其后的是一个中心HSP90结合结构域。CDC37通过保护新合成的激酶肽段使其不被降解从而进入下一步成熟过程，从而募集并稳定了HSP复合物中的激酶（4,5）。CDC37也能抑制HSP90的ATPase活性，因此使复合物发生构象变化而排除靶激酶进入（6）。由于CDC37在增殖和癌细胞生存过程中涉及的多种激酶通路中发挥了重要功能，包括Raf, Akt, Src, 和ErbB2通路，CDC37被作为了治疗靶点（7,8）。 |
| 存放说明 | -20C |
| 计算分子量 | 50 |
参考图片Western blot analysis of extracts from 293 cells, untreated (-) or treated with λ phosphatase (+), using Phospho-CDC37 (Ser13) (D8P8F) Rabbit mAb (upper) and CDC37 (D11A3) XP® Rabbit mAb #4793 (lower).未处理(-)或经过λ phosphatase (+)处理的293细胞提取物，使用Phospho-CDC37 (Ser13) (D8P8F) Rabbit mAb (上)和 CDC37 (D11A3) XP®Rabbit mAb #4793 (下)进行western blot分析。 |
Western blot analysis of extracts from various cell lines using Phospho-CDC37 (Ser37) (D8P8F) Rabbit mAb.使用Phospho-CDC37 (Ser37) (D8P8F) Rabbit mAb对多种细胞提取物进行western blot分析。 |
