Phospho-FLT3 (Tyr589/591) (30D4) Rabbit mAb
货号：
3464S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 3464S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W |
| 目标/特异性 | Phospho-FLT3 (Tyr589/591) (30D4) Rabbit mAb detects endogenous levels of FLT3 protein only when phosphorylated at tyrosine 589/591. The antibody does not cross-react with other phosphorylated tyrosine kinases. (US Patent No. 7,183,385 and foreign equivalents assigned to Cell Signaling Technology, Inc.) |
| 使用方法 | WB(1:1000) |
性能| 供应商 | CST |
| 背景 | FMS-related tyrosine kinase 3 (FLT3, also called Flk2), is a member of the type III receptor tyrosine kinase family, which includes c-Kit, PDGFR and M-CSF receptors. FLT3 is expressed on early hematopoietic progenitor cells and supports growth and differentiation within the hematopoietic system (1,2). FLT3 is activated after binding with its ligand FL, which results in a cascade of tyrosine autophosphorylation and tyrosine phosphorylation of downstream targets (3). The p85 subunit of PI3 kinase, SHP2, GRB2 and Shc are associated with FLT3 after FL stimulation (4-6). Tyr589/591 is located in the juxtamembrane region of FLT3 and may play an important role in regulation of FLT3 tyrosine kinase activity. Somatic mutations of FLT3 consisting of internal tandem duplications (ITDs) occur in 20% of patients with acute myeloid leukemia (7). |
| 存放说明 | -20C |
| 计算分子量 | 160 |
参考图片Western blot analysis of extracts from cells expressing various activated tyrosine kinase proteins, using Phospho-FLT3 (Tyr589/591) (30D4) Rabbit mAb (upper) or Phospho-Tyrosine mAb (P-Tyr-100) #9411 (lower). Phospho-FLT3 (Tyr589/591) (30D4) Rabbit mAb specifically recognizes the activated FLT3 but not non-phosphorylated FLT3 protein.Western blot检测表达各种表达活化酪氨酸激酶蛋白的细胞，使用的抗体为：Phospho-FLT3 (Tyr589/591) (30D4) Rabbit mAb (上) 或Phospho-Tyrosine mAb (P-Tyr-100) #9411 (下)。Phospho-FLT3 (Tyr589/591) (30D4) Rabbit mAb特意识别激活的FLT3但不识别non-phosphorylated FLT3。 |
