Phospho-FLT3 (Tyr842) (10A8) Rabbit mAb
货号：
4577S 基本售价：
3980.0 元 规格：
-
产品信息
概述| 货号 | 4577S |
| 反应种属 | Human/Mouse |
| 来源宿主 | Rabbit |
| 应用 | W/IP |
| 目标/特异性 | Phospho-FLT3 (Tyr842) (10A8) Rabbit mAb detects endogenous levels of FLT3 only when phosphorylated at Tyr842. This antibody may cross-react with other tyrosine-phosphorylated family members. |
| 使用方法 | WB(1:1000)
IP (1:50) |
性能| 供应商 | CST |
| 背景 | FMS-related tyrosine kinase 3 (FLT3, also called Flk2), is a member of the type III receptor tyrosine kinase family, which includes c-Kit, PDGFR and M-CSF receptors. FLT3 is expressed on early hematopoietic progenitor cells and supports growth and differentiation within the hematopoietic system (1,2). FLT3 is activated after binding with its ligand FL, which results in a cascade of tyrosine autophosphorylation and tyrosine phosphorylation of downstream targets (3). The p85 subunit of PI3 kinase, SHP2, GRB2 and Shc are associated with FLT3 after FL stimulation (4-6). Tyr589/591 is located in the juxtamembrane region of FLT3 and may play an important role in regulation of FLT3 tyrosine kinase activity. Somatic mutations of FLT3 consisting of internal tandem duplications (ITDs) occur in 20% of patients with acute myeloid leukemia (7). |
| 存放说明 | -20C |
| 计算分子量 | 160 |
参考图片Western blot analysis of cell extracts from SEM cells expressing constitutively activated FLT3 using Phospho-FLT3 (Tyr842) (10A8) Rabbit mAb (upper and middle). The middle blot was treated with calf intestinal phosphatase (CIP) before antibody probing. Total FLT3 (8F2) Rabbit mAb #3462 shown at the bottom.检测组成型表达激活的FLT3的SEM细胞的提取物，使用的抗体为Phospho-FLT3 (Tyr842) (10A8) Rabbit mAb（上，中）。中，抗体孵育前用intestinal phosphatase (CIP)处理；下，用抗体FLT3 (8F2) Rabbit mAb #3462检测的结果。 |
